{"id":"W1991836995","doi":"10.1038/sj.bjc.6602098","title":"Sustained antiproliferative mechanisms by RB24, a targeted precursor of multiple inhibitors of epidermal growth factor receptor and a DNA alkylating agent in the A431 epidermal carcinoma of the vulva cell line","year":2004,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Health Canada; Royal Victoria Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Epidermal growth factor receptor; A431 cells; Biology; Epidermal growth factor; Tyrosine kinase; Epidermoid carcinoma; Cancer research; Autophosphorylation; DNA synthesis; Molecular biology; Biochemistry; DNA; Kinase; Receptor; Cell cycle; Cancer; Cell; Protein kinase A; Oncogene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009126378,0.0003389557,0.0002219389,0.0001743868,0.0001016469,0.0002315031,0.0001866885,0.0002114329,0.0008695265],"category_scores_gemma":[0.00006664098,0.0001095374,0.0002751196,0.00009680806,0.0001103192,0.0001581971,0.0001275412,0.0003635885,0.0002215004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001626759,"about_ca_system_score_gemma":0.0001691246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004915278,"about_ca_topic_score_gemma":0.0007389368,"domain_scores_codex":[0.9999087,0.00001348015,0.000007582924,0.00001925786,0.0000291724,0.00002172533],"domain_scores_gemma":[0.9999604,0.000005512042,0.00001302413,0.000007379769,0.000006749523,0.000006871974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005043424,0.00001539963,0.00004730897,0.00001369201,0.000003392115,0.00002453077,0.000007815636,0.00005602343,0.9988716,0.00003534941,0.000009507434,0.0008648325],"study_design_scores_gemma":[0.000005877225,0.0003433067,0.0007436474,0.000001199749,0.000008068732,0.0001067002,0.000007418846,0.0002101,0.9977597,0.000007198922,0.0008055329,0.000001275008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996169,0.001723546,0.0011429,0.0000307922,0.00001290142,0.000017808,0.00008342406,0.00004778308,0.0007717687],"genre_scores_gemma":[0.9953892,0.000832764,0.001446447,0.00001366866,0.000005516621,0.00002764752,0.0001472987,0.000008168297,0.002129314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008695265,"threshold_uncertainty_score":0.002908826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01893016801825982,"score_gpt":0.2920890244876561,"score_spread":0.2731588564693963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}