{"id":"W1991839530","doi":"10.1016/j.nbd.2007.08.002","title":"Neurogenic responses to amyloid-beta plaques in the brain of Alzheimer’s disease-like transgenic (pPDGF-APPSw,Ind) mice","year":2007,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences","funders":"National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Neurogenesis; Genetically modified mouse; Transgene; Amyloid beta; Biology; Neural stem cell; Nestin; Hippocampal formation; Subgranular zone; Hippocampus; Neuroscience; Pathology; Cell biology; Stem cell; Subventricular zone; Medicine; Disease; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006877718,0.0004284396,0.0005232377,0.000494595,0.0001429389,0.0000213867,0.001200997,0.00009507509,0.00004853097],"category_scores_gemma":[0.001155808,0.0003496741,0.0003670089,0.0008892353,0.0004651294,0.0001226527,0.0001750022,0.0003269923,0.00003774226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001128513,"about_ca_system_score_gemma":0.0001877538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001308955,"about_ca_topic_score_gemma":0.00002971853,"domain_scores_codex":[0.9951878,0.001614259,0.0009104162,0.001062466,0.0004538926,0.000771202],"domain_scores_gemma":[0.9950537,0.003176665,0.0002903538,0.0009004226,0.0000597011,0.0005191192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004337101,0.0006808416,0.002773969,0.00004729683,0.00001338655,0.0001919442,0.0001956075,0.00008242392,0.9892544,0.001889167,0.0003340409,0.0001998004],"study_design_scores_gemma":[0.0007776617,0.0007844629,0.1486542,0.00002689219,0.0001668378,0.00001441435,0.00003154469,0.00001743576,0.8481625,0.0001516778,0.0009251707,0.0002871462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956644,0.000156985,0.00009738054,0.002029283,0.0004987474,0.001013917,0.0004005497,0.00007073602,0.00006799911],"genre_scores_gemma":[0.9874161,0.00008173175,0.00002511533,0.0122643,0.00005782992,0.00004186849,0.000008268676,0.00006031882,0.00004438734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1458802,"threshold_uncertainty_score":0.9998955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04648046128730077,"score_gpt":0.2979835503237681,"score_spread":0.2515030890364673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}