{"id":"W1991902515","doi":"10.4161/bioa.22549","title":"The role of the cofilin-actin rod stress response in neurodegenerative diseases uncovers potential new drug targets","year":2012,"lang":"en","type":"letter","venue":"BioArchitecture","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Drug; Neuroscience; Cofilin; Actin; Drug response; Fight-or-flight response; Biology; Medicine; Cell biology; Genetics; Pharmacology; Actin cytoskeleton; Cytoskeleton; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003577776,0.0005487509,0.001024554,0.000588157,0.0002791063,0.0007893611,0.0004412803,0.0008616208,0.002429953],"category_scores_gemma":[0.0001929758,0.0001694899,0.0005124594,0.0003420193,0.0003638018,0.0006932747,0.0003921027,0.001545753,0.0007250755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004266784,"about_ca_system_score_gemma":0.0003998688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000410825,"about_ca_topic_score_gemma":0.001346092,"domain_scores_codex":[0.999911,0.00001472805,0.000005886011,0.00001882897,0.00001789397,0.00003172838],"domain_scores_gemma":[0.9998883,0.00002061869,0.00002381799,0.00000793014,0.00003362051,0.00002567136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002253102,0.001638476,0.003623978,0.005353574,0.0003189726,0.001949199,0.0002924484,0.003499834,0.3852181,0.01886941,0.0190747,0.5579082],"study_design_scores_gemma":[0.001322613,0.01365631,0.0239032,0.001783727,0.001084501,0.005854409,0.0007273665,0.01094275,0.1983488,0.02518549,0.7169806,0.0002102633],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.1359294,0.8225762,0.01464297,0.01085177,0.001076921,0.0002941483,0.001021817,0.0007466786,0.01286005],"genre_scores_gemma":[0.4570583,0.520565,0.006431859,0.002787181,0.0007826627,0.0002781438,0.001205057,0.0000620563,0.01082969],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.002429953,"threshold_uncertainty_score":0.00812906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003475724480978501,"score_gpt":0.205404372247034,"score_spread":0.2019286477660555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}