{"id":"W1991912173","doi":"10.1016/s0006-2952(01)00744-4","title":"Induction of CYP2B1/2 and nicotine metabolism by ethanol in rat liver but not rat brain22Abbreviations: CYP, cytochrome P450; C8 xanthate, potassium octylxanthate; NCO, nicotine C-oxidation; NDMA, N-nitrosodimethylamine; NMA, N-nitroso-N-methylaniline; NNK, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; and SSC, saline-sodium citrate buffer.","year":2001,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research; Medical Research Council Canada","keywords":"Nicotine; Chemistry; Microsome; Endocrinology; Internal medicine; Ethanol; Cytochrome P450; Toxicity; Saline; Pharmacology; Metabolism; Biochemistry; Biology; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.002520895,0.001381831,0.002090036,0.0009652165,0.0004310113,0.00009605594,0.0008777818,0.001626543,0.001596233],"category_scores_gemma":[0.0005824868,0.00140479,0.0003381367,0.001526477,0.001646847,0.0005948403,0.0006988511,0.002654817,0.00007870743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002022945,"about_ca_system_score_gemma":0.0003266554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002559906,"about_ca_topic_score_gemma":0.00001457386,"domain_scores_codex":[0.9908452,0.002298998,0.002409545,0.001928455,0.0006867808,0.001831034],"domain_scores_gemma":[0.9947781,0.00177687,0.001151542,0.0005812441,0.0006525738,0.001059701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002449868,0.001530053,0.001438361,0.0002849954,0.0004758506,0.00008512039,0.0003565217,0.00005540859,0.974649,0.0001459646,0.01601068,0.002518243],"study_design_scores_gemma":[0.01173392,0.0003011116,0.003001203,0.0000422005,0.001202034,0.0002702852,0.0001278898,0.002688916,0.9454926,0.0002920504,0.03359036,0.001257444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9551473,0.03573199,0.000305853,0.002624409,0.002783168,0.001988352,0.0009592475,0.0001944343,0.0002652037],"genre_scores_gemma":[0.9631248,0.02828062,0.001109286,0.003964183,0.001352394,0.0003556607,0.0008176829,0.000165049,0.0008303003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02915635,"threshold_uncertainty_score":0.9998932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04710211895602214,"score_gpt":0.3553460143880339,"score_spread":0.3082438954320118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}