{"id":"W1991912173","doi":"10.1016/s0006-2952(01)00744-4","title":"Induction of CYP2B1/2 and nicotine metabolism by ethanol in rat liver but not rat brain22Abbreviations: CYP, cytochrome P450; C8 xanthate, potassium octylxanthate; NCO, nicotine C-oxidation; NDMA, N-nitrosodimethylamine; NMA, N-nitroso-N-methylaniline; NNK, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; and SSC, saline-sodium citrate buffer.","year":2001,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research; Medical Research Council Canada","keywords":"Nicotine; Chemistry; Microsome; Endocrinology; Internal medicine; Ethanol; Cytochrome P450; Toxicity; Saline; Pharmacology; Metabolism; Biochemistry; Biology; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001341138,0.0006368048,0.0002704841,0.0006108528,0.0002859742,0.0002532218,0.0001817684,0.000202099,0.005177824],"category_scores_gemma":[0.0001792625,0.0003258472,0.0004621505,0.0004217503,0.0002767525,0.0002227697,0.0002820846,0.0005336313,0.001586874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006361339,"about_ca_system_score_gemma":0.0004042535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004938649,"about_ca_topic_score_gemma":0.01011487,"domain_scores_codex":[0.9998074,0.00003606057,0.00001338252,0.0000402896,0.00004691046,0.00005593102],"domain_scores_gemma":[0.9998221,0.00002220935,0.00003415678,0.00004270485,0.00003361357,0.00004525621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003587777,0.00005181263,0.0004547667,0.00003969041,0.00001898307,0.00012755,0.00003856672,0.00002525522,0.9962776,0.0001721745,0.0001154345,0.002319243],"study_design_scores_gemma":[0.00001687378,0.0002835965,0.01567809,0.000009651982,0.00003949673,0.0003483225,0.00003076921,0.0002186141,0.9806454,0.00005971939,0.002663454,0.000006094079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801675,0.005286144,0.004948199,0.0002512978,0.000100365,0.00006805562,0.001806121,0.0002611375,0.007111053],"genre_scores_gemma":[0.9562137,0.002915591,0.003473593,0.00008842829,0.00003957391,0.0001174768,0.006437766,0.0001398124,0.03057405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005177824,"threshold_uncertainty_score":0.01732153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04710211895602214,"score_gpt":0.3553460143880339,"score_spread":0.3082438954320118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}