{"id":"W1991912458","doi":"10.1038/emboj.2008.179","title":"Germline V‐genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus","year":2008,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of Toronto; Ontario Institute for Cancer Research; University of British Columbia","funders":"Argonne National Laboratory; Biological and Environmental Research; National Center for Research Resources; Canadian Institutes of Health Research; Canada Research Chairs; National Institutes of Health; Michael Smith Health Research BC; University of Chicago; U.S. Department of Energy","keywords":"Biology; Germline; Virology; Human cytomegalovirus; Antibody; Gene; Cytomegalovirus; Genetics; Binding site; Molecular biology; Virus; Herpesviridae; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001386341,0.0001870914,0.0005309859,0.0003075779,0.0008432887,0.00003602866,0.0003679327,0.00006429266,0.0001840994],"category_scores_gemma":[0.0000765565,0.0000950756,0.0003564279,0.0004754579,0.0006247829,0.0001265952,0.0001344691,0.0007319454,0.00004121819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005312019,"about_ca_system_score_gemma":0.0002080895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003296896,"about_ca_topic_score_gemma":0.00003757244,"domain_scores_codex":[0.9977633,0.0001790832,0.0006933024,0.0001509072,0.0007841515,0.0004292533],"domain_scores_gemma":[0.9985514,0.0001837624,0.0003673723,0.0004336115,0.0003249752,0.0001389343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003863071,0.0001740782,0.05685347,0.0001034858,0.0003410238,0.0001992548,0.00373901,0.00006590055,0.9328833,0.0002335664,0.002602946,0.002417685],"study_design_scores_gemma":[0.005775466,0.001315674,0.7203339,0.001025648,0.0005508938,0.00753804,0.00297551,0.0004434551,0.223183,0.0004689473,0.03587782,0.0005116418],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912664,0.005042463,0.00003110974,0.0008630239,0.0001113107,0.0002410787,0.00002277042,0.00001601857,0.002405867],"genre_scores_gemma":[0.9940435,0.004195489,0.000133961,0.0001629446,0.0004933,0.000003082142,0.000004095925,0.00003200382,0.0009316302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7097002,"threshold_uncertainty_score":0.6485981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08851717364478087,"score_gpt":0.3551815177208029,"score_spread":0.266664344076022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}