{"id":"W1991912458","doi":"10.1038/emboj.2008.179","title":"Germline V‐genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus","year":2008,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of Toronto; Ontario Institute for Cancer Research; University of British Columbia","funders":"Argonne National Laboratory; Biological and Environmental Research; National Center for Research Resources; Canadian Institutes of Health Research; Canada Research Chairs; National Institutes of Health; Michael Smith Health Research BC; University of Chicago; U.S. Department of Energy","keywords":"Biology; Germline; Virology; Human cytomegalovirus; Antibody; Gene; Cytomegalovirus; Genetics; Binding site; Molecular biology; Virus; Herpesviridae; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001259757,0.0003804568,0.0001628173,0.0003578646,0.0002491779,0.0002990239,0.000452478,0.0004117558,0.001442122],"category_scores_gemma":[0.0002466814,0.0001953336,0.0002906733,0.0001615532,0.0002699647,0.0001552656,0.0002753458,0.000784789,0.0006020565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004273721,"about_ca_system_score_gemma":0.0001805236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001188407,"about_ca_topic_score_gemma":0.00132009,"domain_scores_codex":[0.9998615,0.00001663847,0.000004686646,0.00002892564,0.00004048293,0.00004779139],"domain_scores_gemma":[0.9997954,0.00006430119,0.00004065679,0.00002670231,0.00002474287,0.00004818252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004482748,0.00001492121,0.0005652193,0.000008536044,0.000006302314,0.00009479928,0.00001199336,0.0001313337,0.9966359,0.0003048173,0.00008795379,0.002093483],"study_design_scores_gemma":[0.00003758198,0.0002773804,0.01336255,0.000008441599,0.00002939761,0.001703708,0.0000475388,0.002857617,0.9739848,0.0004402161,0.007240042,0.00001060044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922759,0.0006725714,0.004026055,0.00005389227,0.00002892659,0.00001438299,0.0000732853,0.00007045493,0.002784556],"genre_scores_gemma":[0.9959409,0.0002220877,0.001690013,0.0001045388,0.00001342394,0.000007344793,0.0001807045,0.0000293003,0.001811591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001442122,"threshold_uncertainty_score":0.0048244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08851717364478087,"score_gpt":0.3551815177208029,"score_spread":0.266664344076022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}