{"id":"W1991918870","doi":"10.1124/dmd.105.004564","title":"THE SIGNAL TRANSDUCTION PATHWAYS INVOLVED IN HEPATIC CYTOCHROME P450 REGULATION IN THE RAT DURING A LIPOPOLYSACCHARIDE-INDUCED MODEL OF CENTRAL NERVOUS SYSTEM INFLAMMATION","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Signal transduction; Biology; Inflammation; Central nervous system; Activator (genetics); Cytochrome P450; Transcription factor; Ccaat-enhancer-binding proteins; Cell biology; Molecular biology; Endocrinology; Receptor; Nuclear protein; Immunology; Biochemistry; Gene; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005496449,0.0001569836,0.0002803001,0.0001611887,0.0001595767,0.00003214954,0.00007466391,0.0000851775,0.000003182582],"category_scores_gemma":[0.000006214181,0.0001002856,0.00008152453,0.0002221518,0.0000404263,0.0003271966,0.000005618093,0.0001676113,7.889159e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008339575,"about_ca_system_score_gemma":0.00004997106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000114827,"about_ca_topic_score_gemma":0.0006709308,"domain_scores_codex":[0.9985397,0.0001291897,0.0005354451,0.0002050473,0.0003464646,0.0002440804],"domain_scores_gemma":[0.9995337,0.00003068698,0.0001461725,0.0001855066,0.0000514623,0.00005243669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005636811,0.00008388401,0.0002577241,0.0002969762,0.00001216751,0.000005847877,0.007585356,0.00417964,0.9719585,0.009995493,8.731643e-7,0.005059809],"study_design_scores_gemma":[0.003180514,0.00003299203,0.3604162,0.000534254,0.0002367047,0.00002239838,0.004724109,0.148753,0.4808599,0.00102622,0.000007649168,0.000206129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957317,0.0004876262,0.002190042,0.0006305053,0.0000810567,0.0007886415,0.00000797371,0.0000311605,0.00005134214],"genre_scores_gemma":[0.9992865,0.000147861,0.0001555287,0.00002073095,0.0002118635,0.00008078862,0.00006369086,0.00001415265,0.00001889231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4910987,"threshold_uncertainty_score":0.4089529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009952028921445954,"score_gpt":0.2061013829461505,"score_spread":0.1961493540247045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}