{"id":"W1991918870","doi":"10.1124/dmd.105.004564","title":"THE SIGNAL TRANSDUCTION PATHWAYS INVOLVED IN HEPATIC CYTOCHROME P450 REGULATION IN THE RAT DURING A LIPOPOLYSACCHARIDE-INDUCED MODEL OF CENTRAL NERVOUS SYSTEM INFLAMMATION","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Signal transduction; Biology; Inflammation; Central nervous system; Activator (genetics); Cytochrome P450; Transcription factor; Ccaat-enhancer-binding proteins; Cell biology; Molecular biology; Endocrinology; Receptor; Nuclear protein; Immunology; Biochemistry; Gene; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000195796,0.000556561,0.000305635,0.0004995336,0.0002683963,0.0003305212,0.000142832,0.0003302488,0.0008767721],"category_scores_gemma":[0.0002009473,0.0002367226,0.0003618454,0.0002349203,0.000591462,0.0005066492,0.0001481759,0.000881628,0.0002007211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004472973,"about_ca_system_score_gemma":0.0003388534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001001552,"about_ca_topic_score_gemma":0.001489444,"domain_scores_codex":[0.9998928,0.00002478153,0.000005183495,0.00001178891,0.00001627086,0.00004914761],"domain_scores_gemma":[0.9998374,0.00002664429,0.00005769663,0.00001969717,0.0000196191,0.00003887995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006676937,0.0002199106,0.0008475611,0.00005567123,0.0000129598,0.0005226156,0.00006899358,0.0002088168,0.9880747,0.0004265064,0.00005971239,0.00282567],"study_design_scores_gemma":[0.0001266475,0.002107849,0.0272866,0.00002182732,0.00008062501,0.0003968865,0.0002244217,0.00149183,0.967229,0.0004954562,0.0005186143,0.00002025671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976079,0.0006781527,0.001008268,0.0001096887,0.00001541167,0.00001970989,0.0001274415,0.00002332806,0.0004098976],"genre_scores_gemma":[0.9965137,0.0009702257,0.0008791031,0.00003844416,0.00001212565,0.00004924502,0.000217904,0.000006958201,0.001312362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001001552,"threshold_uncertainty_score":0.003245413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009952028921445954,"score_gpt":0.2061013829461505,"score_spread":0.1961493540247045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}