{"id":"W1991919068","doi":"10.1021/bi9007319","title":"Morphology and Secondary Structure of Stable β-Oligomers Formed by Amyloid Peptide PrP(106−126)","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Circular dichroism; Peptide; Chemistry; Thioflavin; Monomer; Amyloid (mycology); Protein secondary structure; Biophysics; Oligomer; Morphology (biology); Fibril; Membrane; Protein structure; Beta sheet; Crystallography; Biochemistry; Polymer chemistry; Polymer; Biology; Organic chemistry; Alzheimer's disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003078593,0.0001584195,0.0002597037,0.00003536858,0.00004556138,0.000008423186,0.00006762842,0.0001375914,0.0004227947],"category_scores_gemma":[0.00003566944,0.0001335878,0.00005893219,0.00009083139,0.000148705,0.00004622404,0.00002972558,0.000160909,0.000004816781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005097648,"about_ca_system_score_gemma":0.0002386396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002566009,"about_ca_topic_score_gemma":6.923314e-7,"domain_scores_codex":[0.9990224,0.00001047864,0.0001683079,0.0002681295,0.0002091973,0.0003215265],"domain_scores_gemma":[0.9992498,0.00001932969,0.00006610755,0.0002632195,0.00006559177,0.0003359962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004192419,0.0002490299,0.01101575,0.0002317578,0.001014561,0.00009011628,0.00003473567,8.634069e-8,0.9676707,0.000006377052,0.01693848,0.002329119],"study_design_scores_gemma":[0.002386334,0.0003325882,0.01936336,0.00005216076,0.0001888869,0.0001326161,0.0001222685,0.000005366608,0.9766207,0.0001978787,0.0004663175,0.0001314639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869334,0.009365672,0.000002139998,0.0002750491,0.00001416168,0.0001900889,0.0003957755,0.00002395535,0.002799808],"genre_scores_gemma":[0.9982138,0.0002016909,0.0002764206,0.0001878895,0.00004742421,0.000004305627,0.0004555059,0.00001239573,0.000600514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01647216,"threshold_uncertainty_score":0.5447553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008413016532037644,"score_gpt":0.2682960444517352,"score_spread":0.2598830279196976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}