{"id":"W1991923050","doi":"10.1038/ncomms6073","title":"Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Cancer Institute; Associazione Italiana per la Ricerca sul Cancro; European Commission; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Israel Cancer Research Fund","keywords":"Receptor tyrosine kinase; Signal transduction; Epidermal growth factor receptor; Circadian clock; Signalling; Receptor; Circadian rhythm; Kinase; Hormone; Biology; Endocrinology; Homeostasis; Internal medicine; Tyrosine kinase; Glucocorticoid receptor; EGFR inhibitors; Cancer research; Cell biology; Glucocorticoid; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002425666,0.000170161,0.0002208486,0.0001601515,0.0001288989,0.0003759027,0.0002531711,0.0001816547,0.0007156054],"category_scores_gemma":[0.0002588113,0.00005236021,0.0001924046,0.0001039142,0.0002193046,0.0001962921,0.0001267221,0.0004859311,0.0001280393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007234642,"about_ca_system_score_gemma":0.0004059883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001587367,"about_ca_topic_score_gemma":0.003447388,"domain_scores_codex":[0.9999112,0.00002817539,0.000006285485,0.0000103231,0.00002473066,0.00001933055],"domain_scores_gemma":[0.9998726,0.00001451898,0.00004906761,0.00001356785,0.00001804779,0.00003216987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003777667,0.0003557507,0.01074518,0.0006520091,0.0001138907,0.0009723337,0.0002438246,0.0009213591,0.7556183,0.005383139,0.004412802,0.2168039],"study_design_scores_gemma":[0.0003860018,0.00532178,0.4327526,0.0003967161,0.0003862875,0.005223453,0.001128227,0.004604769,0.4087242,0.008445421,0.1324955,0.0001350603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7662354,0.2049386,0.006980271,0.007082463,0.0008808482,0.0000635867,0.0007050685,0.0002945052,0.01281934],"genre_scores_gemma":[0.9742169,0.02295108,0.0008615305,0.0003419488,0.0001510062,0.00002155781,0.0001315573,0.00001670526,0.001307631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001587367,"threshold_uncertainty_score":0.005249143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0290338367761179,"score_gpt":0.3305259120725044,"score_spread":0.3014920752963865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}