{"id":"W1991923050","doi":"10.1038/ncomms6073","title":"Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Cancer Institute; Associazione Italiana per la Ricerca sul Cancro; European Commission; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Israel Cancer Research Fund","keywords":"Receptor tyrosine kinase; Signal transduction; Epidermal growth factor receptor; Circadian clock; Signalling; Receptor; Circadian rhythm; Kinase; Hormone; Biology; Endocrinology; Homeostasis; Internal medicine; Tyrosine kinase; Glucocorticoid receptor; EGFR inhibitors; Cancer research; Cell biology; Glucocorticoid; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010683,0.00009175108,0.0001270604,0.00005135618,0.0003781018,0.00002958051,0.0002260572,0.0001172249,0.000001676361],"category_scores_gemma":[0.0002788942,0.00007372317,0.0000338224,0.0001034322,0.0001693654,0.00008635862,0.0001003051,0.0001860604,4.844526e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002152224,"about_ca_system_score_gemma":0.00002436416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003231991,"about_ca_topic_score_gemma":0.000009722486,"domain_scores_codex":[0.9993515,0.00008972938,0.0001793186,0.0001903854,0.00006407096,0.0001249975],"domain_scores_gemma":[0.9985049,0.00072592,0.0001227422,0.0005056391,0.00005026892,0.00009050503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001326658,0.0001411509,0.00436585,0.00001051983,0.00000371754,4.084674e-8,0.0001805294,0.00000121535,0.9038749,0.06242267,0.0003742064,0.02861189],"study_design_scores_gemma":[0.001325302,0.0002932416,0.03792222,0.000109792,0.00006563528,0.00003677298,0.00003846172,0.003862131,0.8525497,0.002047071,0.1015489,0.0002007718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9618242,0.01898284,0.003202236,0.01302608,0.00009796184,0.001239272,0.0002395365,0.00008098745,0.001306897],"genre_scores_gemma":[0.9944171,0.002003438,0.003215048,0.0001149567,0.00002262737,0.0001341679,0.000028144,0.00001166706,0.00005281256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1011747,"threshold_uncertainty_score":0.3006344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0290338367761179,"score_gpt":0.3305259120725044,"score_spread":0.3014920752963865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}