{"id":"W1991940271","doi":"10.2217/nnm.14.158","title":"Nanoparticle-based Caspase Sensors","year":2015,"lang":"en","type":"review","venue":"Nanomedicine","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Caspase; Proteases; In vivo; Nanotechnology; Cysteine; Enzyme; Chemistry; In vitro; Apoptosis; Computational biology; Biochemistry; Cell biology; Programmed cell death; Biology; Materials science; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003298548,0.0002896574,0.0006918316,0.00009229979,0.00004074405,0.000009492182,0.0001394136,0.0003991592,0.0000607692],"category_scores_gemma":[0.00005180973,0.0002056729,0.0002039441,0.000158979,0.00006284419,9.415222e-7,0.00004954267,0.0001150891,0.00005500149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004050503,"about_ca_system_score_gemma":0.0003547404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007143694,"about_ca_topic_score_gemma":0.000003336806,"domain_scores_codex":[0.998717,0.00008369608,0.0003516069,0.0003923962,0.0002178409,0.0002375153],"domain_scores_gemma":[0.9990645,0.00001131986,0.0001764386,0.0004729351,0.00009294807,0.000181868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001641085,0.00005236951,7.365275e-7,0.002009729,0.00007004513,0.00003714165,0.000006334934,0.00001232524,0.001862525,0.0000246094,0.006465162,0.9894426],"study_design_scores_gemma":[0.0004828113,0.0003017941,4.017033e-7,0.0009785055,0.0003470549,0.00005014454,0.00000490409,0.00002926533,0.0005113267,0.000007372729,0.9970539,0.0002325463],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002085648,0.9983093,0.0001254737,0.0000419549,0.0004619649,0.0004130741,0.0000249978,0.00001881729,0.0003959056],"genre_scores_gemma":[0.0002223144,0.9941007,0.0001447352,0.00009037244,0.0008524065,0.00004000661,0.001112344,0.0000558738,0.003381284],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9905887,"threshold_uncertainty_score":0.83871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0419443691804985,"score_gpt":0.3284131333479194,"score_spread":0.286468764167421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}