{"id":"W1991965466","doi":"10.1093/oxfordjournals.schbul.a006988","title":"Monozygotic Twins Exhibit Numerous Epigenetic Differences: Clues to Twin Discordance?","year":2003,"lang":"en","type":"article","venue":"Schizophrenia Bulletin","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":312,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; SickKids Foundation; Centre for Addiction and Mental Health; McMaster University; University of Toronto","funders":"National Institute of Mental Health; Crohn's and Colitis Foundation; Beckman Research Institute, City of Hope; University of Toronto; National Alliance for Research on Schizophrenia and Depression; Crohn's and Colitis Foundation of Canada","keywords":"Epigenetics; DNA methylation; Monozygotic twin; Genetics; Biology; Twin study; Zygosity; Methylation; Gene; Gene expression; Heritability","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002127303,0.0002621081,0.00071017,0.0008788506,0.0006456203,0.0005550645,0.0003929875,0.0003397622,0.001516222],"category_scores_gemma":[0.009062275,0.0003122224,0.0002141418,0.0006871432,0.0006052116,0.0002966156,0.0008157437,0.0004303597,0.0001816733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001757206,"about_ca_system_score_gemma":0.0001799365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008862701,"about_ca_topic_score_gemma":0.001309971,"domain_scores_codex":[0.9976795,0.001107286,0.0002415438,0.0004230889,0.0004250694,0.0001234515],"domain_scores_gemma":[0.9972321,0.0009781475,0.0006544421,0.000680348,0.0002686297,0.0001862637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00247916,0.0002137643,0.8690564,0.0002598648,0.0005965948,0.006447011,0.01017341,0.0002689635,0.07174285,0.004776524,0.000524628,0.03346088],"study_design_scores_gemma":[0.00005110178,0.0006900799,0.9667331,0.00005405464,0.0002886021,0.01604101,0.001694822,0.0009865081,0.008492447,0.003147027,0.001791482,0.00002981607],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975039,0.0004645734,0.001250284,0.0000849085,0.00001897458,0.00002179034,0.0000769837,0.000005383796,0.0005731256],"genre_scores_gemma":[0.9984866,0.0001795585,0.0009745411,0.00003342581,0.000008907419,0.00001676014,0.00008781345,0.000004726338,0.0002075871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002127303,"threshold_uncertainty_score":0.01125038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01184004690110788,"score_gpt":0.2378801969021227,"score_spread":0.2260401500010149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}