{"id":"W1991977085","doi":"10.1074/jbc.m112.393637","title":"Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiator VX-770 (Ivacaftor) Opens the Defective Channel Gate of Mutant CFTR in a Phosphorylation-dependent but ATP-independent Manner","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":308,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; SickKids Foundation","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada; Rosalind Franklin University of Medicine and Science; Vertex Pharmaceuticals; Cystic Fibrosis Foundation Therapeutics; Cystic Fibrosis Foundation","keywords":"Ivacaftor; Cystic fibrosis transmembrane conductance regulator; Potentiator; Phosphorylation; Gating; Cystic fibrosis; Mutant; Chemistry; Cell biology; ATP hydrolysis; Mutation; Adenosine triphosphate; Biochemistry; ΔF508; Biophysics; Biology; Pharmacology; Gene; ATPase; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001188245,0.000313725,0.0008403694,0.00007450621,0.00008584331,0.00002474643,0.0004230184,0.0002919684,0.0005394825],"category_scores_gemma":[0.001119483,0.0001804078,0.0003710691,0.0003013239,0.0003650069,0.0002064757,0.0001083908,0.0008759623,0.00001048572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003195071,"about_ca_system_score_gemma":0.0001937126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002452125,"about_ca_topic_score_gemma":0.000001569847,"domain_scores_codex":[0.9969459,0.0001483785,0.001059201,0.000318188,0.0008835527,0.0006447422],"domain_scores_gemma":[0.9976696,0.0004948503,0.0006576879,0.000355465,0.0003932738,0.0004291629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00260624,0.0005478467,0.009404098,0.0002630969,0.000175584,0.00009865435,0.0002492349,0.0001478194,0.9861199,0.00001624394,0.000048077,0.0003232496],"study_design_scores_gemma":[0.002897419,0.0005820973,0.1184234,0.000547345,0.0001340027,0.001080919,0.001259096,0.0001594691,0.8740419,0.0002869399,0.0003398839,0.0002475498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924489,0.005968601,0.0002613639,0.000469163,0.000136142,0.0004346608,0.00008371905,0.00001402043,0.0001834561],"genre_scores_gemma":[0.9981751,0.0003545292,0.0007535854,0.00008032612,0.0003725256,0.00002492892,0.00001335342,0.000024488,0.000201135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.112078,"threshold_uncertainty_score":0.7356816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02388041023847818,"score_gpt":0.2803072104887046,"score_spread":0.2564268002502264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}