{"id":"W1991977085","doi":"10.1074/jbc.m112.393637","title":"Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiator VX-770 (Ivacaftor) Opens the Defective Channel Gate of Mutant CFTR in a Phosphorylation-dependent but ATP-independent Manner","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":308,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; SickKids Foundation","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada; Rosalind Franklin University of Medicine and Science; Vertex Pharmaceuticals; Cystic Fibrosis Foundation Therapeutics; Cystic Fibrosis Foundation","keywords":"Ivacaftor; Cystic fibrosis transmembrane conductance regulator; Potentiator; Phosphorylation; Gating; Cystic fibrosis; Mutant; Chemistry; Cell biology; ATP hydrolysis; Mutation; Adenosine triphosphate; Biochemistry; ΔF508; Biophysics; Biology; Pharmacology; Gene; ATPase; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001234924,0.000243847,0.0002396882,0.0001053734,0.0001010286,0.0002610912,0.0001737881,0.0002676782,0.0006874687],"category_scores_gemma":[0.00009479785,0.0000892098,0.0002201909,0.0001062418,0.0002235152,0.0002226538,0.0001663119,0.0003973425,0.0001493182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003263518,"about_ca_system_score_gemma":0.000214331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000714193,"about_ca_topic_score_gemma":0.0006163615,"domain_scores_codex":[0.999862,0.00002308553,0.000008921764,0.00003095561,0.00004259133,0.00003246741],"domain_scores_gemma":[0.9999567,0.00001236744,0.00001285135,0.000004526651,0.000003802426,0.00000968771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004198823,0.000009883773,0.00007114417,0.00001641101,0.000002463412,0.00001947644,0.000005153017,0.00001518639,0.9994795,0.00004714218,0.000008577455,0.0002831483],"study_design_scores_gemma":[0.00001264355,0.0002861247,0.002505583,0.000004219669,0.00001138161,0.0001720895,0.00001469877,0.0005703751,0.9954287,0.00002052232,0.0009701575,0.000003493761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972532,0.0008172863,0.001127416,0.00007066628,0.00001704472,0.00001333806,0.0001033196,0.00002676869,0.000570927],"genre_scores_gemma":[0.9966685,0.0007132408,0.00136836,0.00004136514,0.000008754289,0.00001370401,0.0002346984,0.000006683683,0.0009447013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000714193,"threshold_uncertainty_score":0.002367854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02388041023847818,"score_gpt":0.2803072104887046,"score_spread":0.2564268002502264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}