{"id":"W1992011470","doi":"10.1074/jbc.m607897200","title":"Conserved Intermolecular Salt Bridge Required for Activation of Protein Kinases PKR, GCN2, and PERK","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Cancer Institute; National Institutes of Health","keywords":"Protein kinase R; Kinase; Protein kinase domain; Salt bridge; Protein kinase A; EIF-2 kinase; Chemistry; Biology; Cell biology; Biochemistry; Mitogen-activated protein kinase kinase; Cyclin-dependent kinase 2; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001944976,0.000359661,0.0003882695,0.00007415257,0.0002027622,0.0003891124,0.000281376,0.0002830621,0.001069067],"category_scores_gemma":[0.0002518859,0.0001768918,0.0002067429,0.00009969655,0.0003220077,0.0003419665,0.0003562531,0.000418986,0.0004408804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003893917,"about_ca_system_score_gemma":0.000324301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002780421,"about_ca_topic_score_gemma":0.0003807923,"domain_scores_codex":[0.9997934,0.00003717707,0.00001824005,0.00004967171,0.00007594319,0.00002564524],"domain_scores_gemma":[0.9998292,0.00001774741,0.00005950487,0.0000159004,0.00001538831,0.00006235076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002411376,0.00004313348,0.0004401086,0.0000380944,0.000008162928,0.0001691141,0.00002253676,0.0002509294,0.9976904,0.0002664606,0.00003165461,0.0007982591],"study_design_scores_gemma":[0.00009939868,0.0001966182,0.00702587,0.000006303681,0.00001590749,0.0009240172,0.00004476991,0.003777557,0.9858719,0.0002351126,0.001783923,0.00001871308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971836,0.0002852741,0.001704143,0.00003664538,0.00001904857,0.00001757793,0.00005705225,0.00004600275,0.0006505827],"genre_scores_gemma":[0.9971442,0.000125417,0.001853786,0.00002966757,0.000007797836,0.00001724968,0.0002369442,0.00001617518,0.0005686887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001069067,"threshold_uncertainty_score":0.003576398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02889469058372196,"score_gpt":0.2861287771519152,"score_spread":0.2572340865681932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}