{"id":"W1992055191","doi":"10.1016/j.taap.2007.04.016","title":"Benzene’s metabolites alter c-MYB activity via reactive oxygen species in HD3 cells☆","year":2007,"lang":"en","type":"article","venue":"Toxicology and Applied Pharmacology","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Reactive oxygen species; Chemistry; Glutathione; Metabolite; MYB; Hydroquinone; Benzoquinone; Biochemistry; Pharmacology; Biology; Transcription factor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005241571,0.0002757143,0.0003511783,0.0001219806,0.0001262749,0.00001114561,0.0002219257,0.0004774285,0.000206345],"category_scores_gemma":[0.00001358789,0.0002705908,0.00005912589,0.0001474429,0.0003750309,0.000008186986,0.0002010648,0.0003658747,0.00001842449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003758658,"about_ca_system_score_gemma":0.0000875753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008278044,"about_ca_topic_score_gemma":0.0000402756,"domain_scores_codex":[0.9983363,0.0001047967,0.0002795297,0.0006047022,0.00008616003,0.0005885427],"domain_scores_gemma":[0.9994122,0.0001072363,0.0001309835,0.0001788591,0.00004016674,0.000130519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008184225,0.0002144914,0.0007259668,0.00003111989,0.00009547742,0.00002541819,0.000119659,0.00003855775,0.9929894,0.000578715,0.0008180229,0.003544714],"study_design_scores_gemma":[0.00132792,0.0001860466,0.00564005,0.000001734322,0.00005598885,0.00003276721,0.00009263826,0.00002158719,0.9586247,0.0005686125,0.03317088,0.0002771061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828327,0.0009260227,0.001460251,0.000166261,0.0004156682,0.0003438805,0.000009403906,0.00002180499,0.01382397],"genre_scores_gemma":[0.9963483,0.0004202752,0.0004354503,0.001354243,0.0005095192,0.00007249013,0.00003931018,0.00002674013,0.0007936556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03436477,"threshold_uncertainty_score":0.9999746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009062430858881506,"score_gpt":0.2667335465767025,"score_spread":0.2576711157178209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}