{"id":"W1992089991","doi":"10.1523/jneurosci.4940-07.2008","title":"Mcl-1 Is a Key Regulator of Apoptosis during CNS Development and after DNA Damage","year":2008,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"National Cancer Institute; Canadian Institutes of Health Research; Stem Cell Network; Heart and Stroke Foundation of Canada","keywords":"Neurogenesis; MCL1; Biology; Apoptosis; Progenitor cell; Programmed cell death; Cell biology; Neural development; Neural stem cell; Neuroscience; Progenitor; Regulator; Nervous system; DNA damage; Stem cell; Downregulation and upregulation; Genetics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001277772,0.0003589947,0.0002119191,0.000466159,0.000299055,0.0004174568,0.0003093539,0.0003001636,0.0008905898],"category_scores_gemma":[0.0001616084,0.0001309832,0.0001691927,0.0001963814,0.0002209708,0.0003285695,0.0003552896,0.0004092408,0.0003377989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006184378,"about_ca_system_score_gemma":0.0002588765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00052314,"about_ca_topic_score_gemma":0.0007177955,"domain_scores_codex":[0.9998268,0.00001725065,0.00001227837,0.00004187651,0.00005558233,0.00004623295],"domain_scores_gemma":[0.9998446,0.00001145681,0.00006409905,0.0000075572,0.00003239964,0.00003992489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001745421,0.00001196159,0.001610967,0.000119184,0.000009975817,0.0001967146,0.00003829516,0.0001193091,0.9891266,0.0003521806,0.0001856731,0.008054559],"study_design_scores_gemma":[0.00002553997,0.000418947,0.0518006,0.00005077917,0.00004021889,0.001733026,0.0001093196,0.0009209941,0.9292801,0.0005622986,0.01503617,0.00002193803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9252031,0.05813511,0.01074584,0.0005258407,0.0001163059,0.00005721462,0.001179125,0.0005108501,0.003526471],"genre_scores_gemma":[0.9857025,0.007121192,0.002539551,0.0000990051,0.0000333334,0.00004566053,0.0008432135,0.00001603309,0.003599575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008905898,"threshold_uncertainty_score":0.004487157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01197751780516083,"score_gpt":0.2181230527330318,"score_spread":0.2061455349278709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}