{"id":"W1992089991","doi":"10.1523/jneurosci.4940-07.2008","title":"Mcl-1 Is a Key Regulator of Apoptosis during CNS Development and after DNA Damage","year":2008,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"National Cancer Institute; Canadian Institutes of Health Research; Stem Cell Network; Heart and Stroke Foundation of Canada","keywords":"Neurogenesis; MCL1; Biology; Apoptosis; Progenitor cell; Programmed cell death; Cell biology; Neural development; Neural stem cell; Neuroscience; Progenitor; Regulator; Nervous system; DNA damage; Stem cell; Downregulation and upregulation; Genetics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009206437,0.00006448026,0.00009184941,0.00005354272,0.00007546494,0.000008612521,0.00009412361,0.0000384542,0.00000347667],"category_scores_gemma":[0.00002550152,0.00005138575,0.000041785,0.00007149005,0.00008584444,0.0000100024,0.00006247574,0.00004130537,2.141641e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000578259,"about_ca_system_score_gemma":0.0000594485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":5.184424e-7,"about_ca_topic_score_gemma":5.097377e-7,"domain_scores_codex":[0.9993715,0.00001373233,0.0002130788,0.0001251796,0.0001765807,0.0000998916],"domain_scores_gemma":[0.9996062,0.000002486741,0.0001584444,0.00009714838,0.00006828026,0.00006742275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003584912,0.00002421976,0.001846581,0.0000106539,0.000002327617,0.000007629315,0.0001704382,0.000012615,0.9975986,0.000003851418,0.00003304595,0.000254112],"study_design_scores_gemma":[0.0001767538,0.0001123778,0.2217295,0.00001441434,0.000003785521,0.0001633254,0.00001149132,0.00002277077,0.7751572,0.000006531692,0.00255295,0.00004883158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992278,0.0001191597,0.0003939338,0.00007258211,0.0001280591,0.00003198434,0.000001200969,0.000001011945,0.00002431148],"genre_scores_gemma":[0.9977823,0.0002251766,0.001427756,0.0001069099,0.00004469505,6.96655e-7,2.167073e-7,0.000005116239,0.0004071239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2224414,"threshold_uncertainty_score":0.209545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01197751780516083,"score_gpt":0.2181230527330318,"score_spread":0.2061455349278709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}