{"id":"W1992104188","doi":"10.1371/journal.pone.0023220","title":"Oligomeric Structure of the MALT1 Tandem Ig-Like Domains","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"Canadian Institutes of Health Research; Basic Energy Sciences; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Office of Science; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust; U.S. Department of Energy","keywords":"IκB kinase; Chemistry; T-cell receptor; Ubiquitin ligase; Cell biology; Tandem; Tetramer; Dimer; Computational biology; Biology; Signal transduction; T cell; NF-κB; Ubiquitin; Genetics; Immune system; Biochemistry; Materials science; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004911174,0.0001029304,0.0001336655,0.00001664589,0.00004570155,0.000003788416,0.0002757218,0.0001122004,0.0001081464],"category_scores_gemma":[0.00003908702,0.00007565167,0.00006562954,0.00008732262,0.00009257156,0.000001401162,0.0001165726,0.0000841994,0.000006364994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006754676,"about_ca_system_score_gemma":0.0000426474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001794815,"about_ca_topic_score_gemma":0.00002632526,"domain_scores_codex":[0.9993071,0.00004189681,0.0001393704,0.0001867599,0.0001639983,0.0001608888],"domain_scores_gemma":[0.9993449,0.000005025024,0.00009227143,0.0004541946,0.00006206388,0.00004149924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001873155,0.0001670003,0.01060563,0.00002393552,0.0001199806,8.25257e-7,0.0001111196,0.000001252423,0.9886518,0.0001158869,0.0001352276,0.00004866104],"study_design_scores_gemma":[0.0002223807,0.0001196803,0.007706614,0.00002680862,0.00005842273,0.000002919279,0.00002203997,0.000004367166,0.9910417,0.0003580757,0.0003394314,0.00009762356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997627,0.0002696678,0.00006372909,0.00002447915,0.00007368563,0.0001357161,0.00003878222,0.000009905182,0.001757069],"genre_scores_gemma":[0.9971341,0.00002994154,0.002048253,0.0002115267,0.0001204652,0.000004241373,0.00001489429,0.00001967217,0.000416922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002899015,"threshold_uncertainty_score":0.3084985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03153044701183183,"score_gpt":0.1987676949061019,"score_spread":0.1672372478942701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}