{"id":"W1992104188","doi":"10.1371/journal.pone.0023220","title":"Oligomeric Structure of the MALT1 Tandem Ig-Like Domains","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"Canadian Institutes of Health Research; Basic Energy Sciences; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Office of Science; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust; U.S. Department of Energy","keywords":"IκB kinase; Chemistry; T-cell receptor; Ubiquitin ligase; Cell biology; Tandem; Tetramer; Dimer; Computational biology; Biology; Signal transduction; T cell; NF-κB; Ubiquitin; Genetics; Immune system; Biochemistry; Materials science; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006221871,0.0003408953,0.0001413473,0.0001907791,0.0001472501,0.0003418851,0.000292644,0.0003175173,0.002469609],"category_scores_gemma":[0.000195983,0.0001087159,0.0002121595,0.0002300518,0.0001130293,0.0002515568,0.0001697905,0.0003716585,0.0005440611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005039222,"about_ca_system_score_gemma":0.0001270338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008670358,"about_ca_topic_score_gemma":0.0007210355,"domain_scores_codex":[0.9999577,0.000003960939,0.00000263111,0.00001640166,0.000009926976,0.000009394381],"domain_scores_gemma":[0.9999194,0.0000118233,0.00002953259,0.000004983064,0.00001258982,0.00002158706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006596493,0.0001504813,0.004130045,0.0001758877,0.00005413169,0.0006058755,0.0001547248,0.003422392,0.9804959,0.001526544,0.0009424768,0.007681835],"study_design_scores_gemma":[0.0001555584,0.0006613453,0.06350647,0.0001152022,0.0002264042,0.003049457,0.0003771746,0.0710182,0.8280436,0.002956759,0.02979824,0.00009151788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943145,0.001281155,0.002620433,0.0001021231,0.00001084246,0.00001045467,0.0004958172,0.00007980911,0.001084911],"genre_scores_gemma":[0.9942324,0.0005012478,0.002174128,0.00005078196,0.00000612192,0.00001090095,0.001698691,0.00001358265,0.001312166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002469609,"threshold_uncertainty_score":0.008261621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03153044701183183,"score_gpt":0.1987676949061019,"score_spread":0.1672372478942701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}