{"id":"W1992118657","doi":"10.1111/j.1365-2036.2009.04037.x","title":"Infliximab and other immunomodulating drugs in patients with inflammatory bowel disease and the risk of serious bacterial infections","year":2009,"lang":"en","type":"article","venue":"Alimentary Pharmacology & Therapeutics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":214,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Procter and Gamble; Pfizer; Amgen","keywords":"Medicine; Infliximab; Ulcerative colitis; Inflammatory bowel disease; Azathioprine; Internal medicine; Clostridium difficile; Thiopurine methyltransferase; Relative risk; Gastroenterology; Crohn's disease; Immunology; Antibiotics; Disease; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000840673,0.0002310277,0.0004404305,0.0008620282,0.0003754517,0.0008902089,0.0002797894,0.0005712525,0.001495596],"category_scores_gemma":[0.004202174,0.0002592803,0.0006487147,0.001820399,0.0002244515,0.0002793022,0.0003935964,0.0007976666,0.0001779407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004727857,"about_ca_system_score_gemma":0.0007536404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01155702,"about_ca_topic_score_gemma":0.01510984,"domain_scores_codex":[0.9987857,0.0004183887,0.0001805038,0.0001491292,0.0003023458,0.0001639595],"domain_scores_gemma":[0.9954269,0.0007678667,0.0027444,0.0001767254,0.0002721653,0.0006118879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008443942,0.00001570417,0.9986081,0.00001483384,0.00006368183,0.00007246863,0.00001777303,0.00002184819,0.0000411866,0.000006600586,0.00006325233,0.0009903349],"study_design_scores_gemma":[0.00001072998,0.00005242157,0.9991691,0.00002043294,0.0000457726,0.000314585,0.00003691665,0.00007889248,0.000019039,0.0000172457,0.000232446,0.000002399043],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950355,0.003255229,0.00007258433,0.0002705759,0.00002058465,0.00001165561,0.0006302572,0.000004113591,0.0006995366],"genre_scores_gemma":[0.9980391,0.001002129,0.0001382745,0.0001133259,0.00003783052,0.000009952459,0.0005066304,0.000001410451,0.0001514103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01155702,"threshold_uncertainty_score":0.0229795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00349494635319812,"score_gpt":0.2290890353356503,"score_spread":0.2255940889824522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}