{"id":"W1992127013","doi":"10.1073/pnas.0914960107","title":"Recovery of PEX1-Gly843Asp peroxisome dysfunction by small-molecule compounds","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Zellweger syndrome; Peroxisome; Biology; Cytosol; Phenotype; Chaperone (clinical); Biochemistry; Medicine; Pathology; Receptor; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001456872,0.0005586288,0.0004802306,0.0003267755,0.0001789358,0.000237696,0.0001752935,0.0002878455,0.001087626],"category_scores_gemma":[0.0001272168,0.0001160429,0.0002893564,0.0002174296,0.0001992025,0.0001358419,0.0001503945,0.0004156883,0.000271368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002435907,"about_ca_system_score_gemma":0.0001865224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004212339,"about_ca_topic_score_gemma":0.001244756,"domain_scores_codex":[0.9999119,0.00001622227,0.000009091202,0.00001519796,0.00002796751,0.00001960676],"domain_scores_gemma":[0.9999338,0.00001960225,0.00001518042,0.000007325427,0.000008973538,0.00001518328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001200886,0.00007100258,0.0001486968,0.00003716076,0.00001052949,0.00006677942,0.000005946174,0.0001042649,0.9971641,0.00003030607,0.00004348731,0.002197579],"study_design_scores_gemma":[0.00004210727,0.0008782268,0.001664018,0.000003586142,0.00001567089,0.0001866866,0.000009559663,0.0003450906,0.9961314,0.00001465683,0.0007052592,0.000003571494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947948,0.001285458,0.002193742,0.00009170877,0.00002080366,0.00009284513,0.0004196982,0.000104112,0.0009968226],"genre_scores_gemma":[0.9912387,0.001417357,0.003830413,0.00006643028,0.000007801015,0.0001049823,0.0008771532,0.00002144464,0.00243579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001087626,"threshold_uncertainty_score":0.003638506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01660038986696742,"score_gpt":0.2597298576118058,"score_spread":0.2431294677448384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}