{"id":"W1992137065","doi":"10.1016/j.molimm.2011.06.368","title":"Interim analysis of phase II efficacy and safety data for eculizumab in patients with atypical hemolytic uremic syndrome (aHUS) receiving chronic plasma exchange/infusion","year":2011,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Eculizumab; Medicine; Atypical hemolytic uremic syndrome; Nausea; Thrombotic microangiopathy; Pediatrics; Internal medicine; Disease; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002335193,0.0002638436,0.0007483744,0.0005394215,0.0001664254,0.000004594682,0.0006135622,0.0002200912,0.0005773244],"category_scores_gemma":[0.0001607321,0.0002394604,0.00009168118,0.0004189711,0.0003087531,0.0000945326,0.001137305,0.0001877639,0.00000808094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001291268,"about_ca_system_score_gemma":0.0000734988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001060096,"about_ca_topic_score_gemma":0.0001598629,"domain_scores_codex":[0.9979686,0.0002974782,0.0006034171,0.0006329389,0.00005301832,0.0004445892],"domain_scores_gemma":[0.9983848,0.0001423849,0.0002798472,0.001085703,0.00008069376,0.00002662129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.08143063,0.01518759,0.1049384,0.0009212565,0.0326585,0.0002324825,0.006434297,0.0001083973,0.6805896,0.001060749,0.0005681024,0.07587002],"study_design_scores_gemma":[0.06345306,0.01646893,0.8934795,0.0007276675,0.003921675,0.0001263335,0.0002349507,0.0007216558,0.01732774,0.00004968029,0.002526457,0.0009624162],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944056,0.002787255,0.001253179,0.00002692902,0.0001666809,0.0009702764,0.0003285249,0.0000334172,0.00002813256],"genre_scores_gemma":[0.9970563,0.00004000109,0.0001950302,0.00002223664,0.000002837866,0.00005748083,0.002575519,0.00002648241,0.00002408222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.788541,"threshold_uncertainty_score":0.9764913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02358326475165973,"score_gpt":0.2695959368923132,"score_spread":0.2460126721406535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}