{"id":"W1992189141","doi":"10.1038/mt.2008.290","title":"Human Neural Stem Cells Can Target and Deliver Therapeutic Genes to Breast Cancer Brain Metastases","year":2009,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital","funders":"","keywords":"Cytosine deaminase; Cancer research; Systemic administration; Immune system; Neural stem cell; In vivo; Prodrug; Medicine; Brain tumor; Transplantation; Cancer cell; Stem cell; Glioma; Cancer; Genetic enhancement; Biology; Pharmacology; Pathology; Immunology; Internal medicine; Gene; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001220333,0.000272828,0.0003481055,0.00008991463,0.0001109126,0.00004381888,0.00008476928,0.0000487479,0.0001848885],"category_scores_gemma":[6.75921e-7,0.0002023571,0.00013057,0.0001573214,0.0000402049,0.00003324012,0.00001646688,0.00009185734,0.000005688749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005152734,"about_ca_system_score_gemma":0.00003181283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002845817,"about_ca_topic_score_gemma":0.00002273935,"domain_scores_codex":[0.9987355,0.0001336793,0.0001842417,0.000375328,0.000240123,0.0003310547],"domain_scores_gemma":[0.9993182,0.00001621565,0.00004789251,0.0003304207,0.00004277549,0.0002445151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002355672,0.0003330095,0.001081455,0.00001304536,0.0004913917,0.0004027819,0.0002847953,0.0001760318,0.5757545,0.000316462,0.0006235704,0.4202873],"study_design_scores_gemma":[0.01193119,0.004815677,0.1327929,0.0001209005,0.000638062,0.0005398533,0.0002869692,0.000325669,0.7962981,0.000582916,0.05055349,0.00111425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654851,0.01498948,0.0003360577,0.01820859,0.0000566893,0.0006812296,0.0001521427,0.00005515014,0.00003553944],"genre_scores_gemma":[0.9709823,0.0002702306,0.0007170929,0.02759865,0.00006677894,0.00004019797,0.0000231276,0.00003704198,0.0002645619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4191731,"threshold_uncertainty_score":0.8251882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02086013316065335,"score_gpt":0.2928128505398481,"score_spread":0.2719527173791947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}