{"id":"W1992199053","doi":"10.3791/51576","title":"Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency","year":2014,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Transgene; Germ cell; Biology; Germline; Population; Somatic cell; Reporter gene; Assay sensitivity; In vivo; Cell; Genetically modified mouse; Mutagen; Mutation; Germline mutation; Genetics; Gene; Cell biology; Gene expression; Medicine; Pathology; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001725116,0.001297918,0.0007019609,0.003382042,0.000462095,0.0004838158,0.000954237,0.00108223,0.006173206],"category_scores_gemma":[0.0008688184,0.0006555452,0.0008448247,0.001111992,0.0005151156,0.0004441077,0.000529799,0.00224711,0.002040133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003840312,"about_ca_system_score_gemma":0.0004104725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005419641,"about_ca_topic_score_gemma":0.001883735,"domain_scores_codex":[0.9976264,0.0005834948,0.0002444976,0.0005539723,0.0008199682,0.0001717017],"domain_scores_gemma":[0.998338,0.0003603604,0.0004947697,0.0002792148,0.0003258746,0.0002018691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009217188,0.0001560932,0.001073607,0.00009756946,0.00003330164,0.00005581892,0.00004818845,0.00006756423,0.9947196,0.0002781943,0.0003061369,0.003071762],"study_design_scores_gemma":[0.00007501574,0.002219283,0.01513692,0.00006233119,0.0002482211,0.0008618173,0.00006005788,0.001929414,0.9683498,0.0002970438,0.01071004,0.00005006179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5022716,0.005683075,0.4563552,0.000372523,0.0005741706,0.003334824,0.01182289,0.005938813,0.01364702],"genre_scores_gemma":[0.4606078,0.007312233,0.4714461,0.0006565197,0.0001441618,0.007524703,0.01783194,0.001400744,0.03307592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006173206,"threshold_uncertainty_score":0.0206514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03789178042956873,"score_gpt":0.397045839877001,"score_spread":0.3591540594474323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}