{"id":"W1992199053","doi":"10.3791/51576","title":"Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency","year":2014,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Transgene; Germ cell; Biology; Germline; Population; Somatic cell; Reporter gene; Assay sensitivity; In vivo; Cell; Genetically modified mouse; Mutagen; Mutation; Germline mutation; Genetics; Gene; Cell biology; Gene expression; Medicine; Pathology; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006503676,0.0001495394,0.000224005,0.00005657804,0.00008679947,0.00002993195,0.000173133,0.000114721,0.00003736652],"category_scores_gemma":[0.00006521055,0.0001235815,0.0002559738,0.0000447733,0.00003204563,0.000006360646,0.00002492759,0.00007471205,0.000003978787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002099981,"about_ca_system_score_gemma":0.00005787571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004657754,"about_ca_topic_score_gemma":0.000001153323,"domain_scores_codex":[0.9987729,0.00009901427,0.0004707567,0.0002374004,0.0002077629,0.0002121691],"domain_scores_gemma":[0.9991319,0.00001126858,0.0003721338,0.0001946627,0.0001887574,0.0001012646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002393596,0.0002033674,0.0006239542,0.00002457703,0.00006794186,0.00000129313,0.0001284565,0.00003328692,0.9975558,0.00007164603,0.0003968434,0.0006534595],"study_design_scores_gemma":[0.001616156,0.001250786,0.0002689864,0.0000192235,0.00004192422,0.00005246491,0.0001238435,0.0001042685,0.970196,0.00006822388,0.02610078,0.0001573104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9321157,0.002194047,0.06432021,0.00005328544,0.0006571826,0.0001753335,0.000003974552,0.000003596597,0.0004767106],"genre_scores_gemma":[0.9911684,0.0003424527,0.007021766,0.00008601676,0.0007009946,0.00001011546,0.00001131581,0.00003041793,0.0006284707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05905279,"threshold_uncertainty_score":0.5039508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03789178042956873,"score_gpt":0.397045839877001,"score_spread":0.3591540594474323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}