{"id":"W1992199975","doi":"10.1002/jcp.10389","title":"EGF mediates protection against Fas‐induced apoptosis by depleting and oxidizing intracellular GSH stocks","year":2003,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Saint-Luc; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Glutathione; Apoptosis; Programmed cell death; Intracellular; Biology; Epidermal growth factor; Reactive oxygen species; Cell biology; Caspase; Biochemistry; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008040834,0.0002412197,0.0001594808,0.0001427203,0.00006949188,0.0001237768,0.0001183794,0.000114229,0.0009837497],"category_scores_gemma":[0.00007520244,0.00005661816,0.0001609439,0.00006171955,0.00007878219,0.0001079357,0.0001276454,0.0003090845,0.0001694381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000094576,"about_ca_system_score_gemma":0.0001480986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000451591,"about_ca_topic_score_gemma":0.0006057283,"domain_scores_codex":[0.9999491,0.00001078162,0.000005939988,0.000006672008,0.00001645051,0.00001107064],"domain_scores_gemma":[0.9999537,0.000007213906,0.00001032579,0.000005547962,0.000009631414,0.00001345091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002421182,0.0000342857,0.0003164072,0.00006390828,0.000007299819,0.00008601932,0.00001415359,0.00003516604,0.9943783,0.00006636252,0.00003612785,0.004719781],"study_design_scores_gemma":[0.0000233197,0.0005639353,0.004965581,0.000008903088,0.00001894428,0.000353354,0.00002810241,0.0003262469,0.9908062,0.00005907245,0.002842687,0.00000383508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892914,0.005435044,0.003202897,0.0001287082,0.00004110292,0.00003430562,0.0001910243,0.00007507106,0.00160041],"genre_scores_gemma":[0.9943259,0.001966309,0.00140092,0.00004931102,0.0000131493,0.00002051258,0.0003362808,0.000006097801,0.001881521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009837497,"threshold_uncertainty_score":0.003290951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009863084919767619,"score_gpt":0.2133493154952114,"score_spread":0.2034862305754438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}