{"id":"W1992222970","doi":"10.1016/s0169-328x(01)00121-8","title":"Upregulation of the immediate early gene arc in the brains of rats exposed to environmental enrichment: implications for molecular plasticity","year":2001,"lang":"en","type":"article","venue":"Molecular Brain Research","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":108,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Heart and Stroke Foundation of Canada","keywords":"Environmental enrichment; Biology; Arc (geometry); Dentate gyrus; Hippocampal formation; In situ hybridization; Downregulation and upregulation; Neuroplasticity; Cerebral cortex; Immediate early gene; Hippocampus; Cortex (anatomy); Neuroscience; Synaptic plasticity; Gene expression; Endocrinology; Internal medicine; Gene; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000077379,0.0004079268,0.0005085015,0.0003752654,0.0002850939,0.0003481776,0.0002787675,0.0002695807,0.001924682],"category_scores_gemma":[0.0001969502,0.0002000592,0.0002042682,0.000144362,0.0006938418,0.0003440355,0.0003492021,0.0008382972,0.0002063292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002786982,"about_ca_system_score_gemma":0.0003047766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001100032,"about_ca_topic_score_gemma":0.002165185,"domain_scores_codex":[0.9998931,0.000009329448,0.000003986509,0.00002637659,0.00002573689,0.00004149873],"domain_scores_gemma":[0.9998241,0.00001829949,0.00004252855,0.00002315141,0.00002333437,0.00006850201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008971494,0.00004939927,0.001413265,0.00004337934,0.00001902126,0.0002122339,0.00005816312,0.00002485124,0.9942708,0.00008462974,0.00005345177,0.002873766],"study_design_scores_gemma":[0.00006919949,0.001284836,0.2321091,0.00002879754,0.0001323646,0.001654278,0.0008794951,0.0004480209,0.760627,0.0008350869,0.001902728,0.00002901084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981601,0.0004084396,0.0006564826,0.0001364618,0.00002846639,0.00000420859,0.0001234118,0.00002934724,0.0004531851],"genre_scores_gemma":[0.9938993,0.0009498919,0.001226366,0.0001042197,0.00002403431,0.00003798828,0.0003283286,0.00004427485,0.003385502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001924682,"threshold_uncertainty_score":0.006438732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08746028536632351,"score_gpt":0.38406387180704,"score_spread":0.2966035864407165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}