{"id":"W1992234352","doi":"10.1371/journal.pone.0054006","title":"Activation of p53 by Chemotherapeutic Agents Enhances Reovirus Oncolysis","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie University; Fondation pour la Recherche Médicale","keywords":"Doxorubicin; Oncolytic virus; Apoptosis; Etoposide; Cancer research; In vivo; Biology; Cancer cell; In vitro; Virology; Cancer; Pharmacology; Virus; Chemotherapy; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001349394,0.0004403119,0.0003453146,0.000333602,0.0001162866,0.0002740037,0.0001484797,0.0002819811,0.001598386],"category_scores_gemma":[0.0001980657,0.0001155638,0.0002741262,0.0001538014,0.0002221358,0.0003290005,0.0001737778,0.0005582577,0.0002810404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002550363,"about_ca_system_score_gemma":0.0001255418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003097836,"about_ca_topic_score_gemma":0.0005071776,"domain_scores_codex":[0.9998556,0.00003525314,0.00001167665,0.00002838013,0.0000350989,0.00003399161],"domain_scores_gemma":[0.999864,0.0000524844,0.0000309653,0.00001867331,0.00001334258,0.00002055656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001179238,0.00004336908,0.00009400477,0.00003120798,0.000005450303,0.00003549454,0.000009645606,0.0001095772,0.9975172,0.00007847617,0.00003179299,0.001925826],"study_design_scores_gemma":[0.00001307293,0.0004050217,0.00102711,0.000004129657,0.00001289109,0.00009549291,0.000005723768,0.0005023588,0.9969184,0.00003096374,0.0009828369,0.000002025492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871897,0.004699037,0.004648529,0.0001648797,0.00007006179,0.00006054658,0.000145668,0.0001218203,0.002899701],"genre_scores_gemma":[0.996294,0.001297962,0.001244522,0.00002666941,0.00001017785,0.00001857154,0.00008768681,0.00001359842,0.001006755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001598386,"threshold_uncertainty_score":0.005347133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04082557738663996,"score_gpt":0.2891066365428313,"score_spread":0.2482810591561914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}