{"id":"W1992234352","doi":"10.1371/journal.pone.0054006","title":"Activation of p53 by Chemotherapeutic Agents Enhances Reovirus Oncolysis","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie University; Fondation pour la Recherche Médicale","keywords":"Doxorubicin; Oncolytic virus; Apoptosis; Etoposide; Cancer research; In vivo; Biology; Cancer cell; In vitro; Virology; Cancer; Pharmacology; Virus; Chemotherapy; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001100516,0.0001037241,0.0001528327,0.00004058142,0.00003858914,0.00001492336,0.0001971822,0.00009915689,0.0005859581],"category_scores_gemma":[0.000037855,0.000100846,0.0000509013,0.0001186082,0.00006173585,0.000006703567,0.00004094326,0.00006652772,0.0000802733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002002555,"about_ca_system_score_gemma":0.00004451532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006010128,"about_ca_topic_score_gemma":0.00001268136,"domain_scores_codex":[0.9990627,0.00006378529,0.0001660697,0.0002272891,0.0002857991,0.0001943883],"domain_scores_gemma":[0.9993758,0.00001364965,0.00008700659,0.0003275382,0.0001383315,0.00005765864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000239247,0.0006665618,0.0004143756,0.00003180669,0.0003112842,4.380804e-8,0.000034177,0.000001674187,0.9915594,6.586112e-7,0.001212464,0.005528318],"study_design_scores_gemma":[0.0003812258,0.001018513,0.0003020236,0.00002222995,0.00002200587,9.611716e-8,0.00002095531,0.00007557357,0.9975641,0.00003657499,0.000451119,0.0001055956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998064,0.0003744946,0.00006619782,0.0002948679,0.000008350183,0.0003117367,0.000009526892,0.000009565419,0.0008612247],"genre_scores_gemma":[0.9964108,0.0005205272,0.0003045096,0.0003763042,0.00007621828,0.00008503401,0.00007112223,0.00002372353,0.002131803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006004699,"threshold_uncertainty_score":0.641583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04082557738663996,"score_gpt":0.2891066365428313,"score_spread":0.2482810591561914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}