{"id":"W1992237229","doi":"10.1371/journal.pone.0074953","title":"Aryl Hydrocarbon Receptor-Dependent Retention of Nuclear HuR Suppresses Cigarette Smoke-Induced Cyclooxygenase-2 Expression Independent of DNA-Binding","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McMaster University; McGill University","funders":"McGill University Health Centre; Natural Sciences and Engineering Research Council of Canada; McGill University; American Thoracic Society","keywords":"Aryl hydrocarbon receptor; Gene knockdown; Messenger RNA; Transcription factor; Chemistry; Cell biology; Cancer research; Biology; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001373034,0.0003076234,0.0003193454,0.000193349,0.0001872224,0.0003220986,0.0002143353,0.0001818195,0.001191952],"category_scores_gemma":[0.000121787,0.0001425119,0.000283072,0.00009384633,0.0003208031,0.0001701248,0.0002318296,0.0005968628,0.0004501806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001913756,"about_ca_system_score_gemma":0.0002517313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005613563,"about_ca_topic_score_gemma":0.001747154,"domain_scores_codex":[0.9998155,0.00003177465,0.00001536674,0.00003181516,0.00004380848,0.00006163544],"domain_scores_gemma":[0.9998474,0.0000246408,0.00003580384,0.00003037792,0.00002004972,0.0000417573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009337457,0.00003526099,0.00004914711,0.0000187408,0.000002860754,0.00001960938,0.00001109687,0.00001816223,0.9990907,0.00005479343,0.00003465299,0.000571561],"study_design_scores_gemma":[0.00002289619,0.0004706005,0.002599471,0.000004293935,0.00001058487,0.0001008394,0.00003844819,0.0006063102,0.9946016,0.00003980737,0.001501292,0.000003928412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938819,0.001756151,0.001941691,0.0001761626,0.00008265636,0.00002736853,0.0002613949,0.000163834,0.001708683],"genre_scores_gemma":[0.9929181,0.0007251485,0.001262623,0.00008441664,0.00003083264,0.00004178401,0.0004050384,0.00003274052,0.004499352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001191952,"threshold_uncertainty_score":0.003987432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0306440185828801,"score_gpt":0.2145843436833612,"score_spread":0.1839403251004811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}