{"id":"W1992246106","doi":"10.1021/ml400466p","title":"Novel Quinoline-Based P2–P4 Macrocyclic Derivatives As Pan-Genotypic HCV NS3/4a Protease Inhibitors","year":2014,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Quinoline; Protease; NS3; Virology; Combinatorial chemistry; Chemistry; Medicine; Enzyme; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001871675,0.0003718389,0.0002947263,0.0002508716,0.000156476,0.0002684623,0.0004777284,0.0002761855,0.001964428],"category_scores_gemma":[0.0001263627,0.0001422247,0.0002026677,0.0001593439,0.000185722,0.0002278331,0.0002603589,0.0003418561,0.000641916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002101296,"about_ca_system_score_gemma":0.0001359852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004984026,"about_ca_topic_score_gemma":0.001332066,"domain_scores_codex":[0.9999255,0.0000197852,0.000004455143,0.00001454255,0.00001598781,0.00001975849],"domain_scores_gemma":[0.999964,0.000005784187,0.000007191182,0.000003558081,0.000007025938,0.00001249166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001148091,0.0003109241,0.0007323302,0.0005595774,0.00006061023,0.001429043,0.0001525051,0.005165684,0.9146219,0.003169885,0.002133637,0.07051574],"study_design_scores_gemma":[0.000903682,0.01247586,0.007245096,0.0001145735,0.0001489182,0.002812936,0.0000878123,0.0149945,0.8678564,0.001354719,0.09188075,0.0001247091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.929285,0.02028069,0.02341033,0.0006420994,0.0002455895,0.0005675092,0.001103587,0.0006173452,0.02384774],"genre_scores_gemma":[0.9780542,0.006879537,0.008736905,0.0002296152,0.00003929755,0.000125148,0.0004041314,0.00003790525,0.005493229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001964428,"threshold_uncertainty_score":0.006571651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01878610217810785,"score_gpt":0.2909391904750037,"score_spread":0.2721530882968958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}