{"id":"W1992259067","doi":"10.1097/aln.0b013e31817f4c5d","title":"Enhancement of Spinal N -Methyl-d-aspartate Receptor Function by Remifentanil Action at δ-Opioid Receptors as a Mechanism for Acute Opioid-induced Hyperalgesia or Tolerance","year":2008,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Remifentanil; NMDA receptor; Hyperalgesia; Opioid; Medicine; Pharmacology; Anesthesia; μ-opioid receptor; Naltrindole; Enkephalin; Opioid receptor; (+)-Naloxone; Receptor; Internal medicine; Nociception","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002006486,0.0003934077,0.0002854377,0.0001252949,0.00006864207,0.000166433,0.0002310048,0.0001815965,0.00105619],"category_scores_gemma":[0.0001310227,0.00009140244,0.0003181457,0.00006306727,0.0001742136,0.0002161398,0.0001095728,0.0003957634,0.0001811661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002089745,"about_ca_system_score_gemma":0.0001148269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002528276,"about_ca_topic_score_gemma":0.0005539649,"domain_scores_codex":[0.9998928,0.00001555288,0.00001399616,0.00001241051,0.00002713298,0.00003804038],"domain_scores_gemma":[0.9999201,0.00001182845,0.000032919,0.000007715291,0.00001348879,0.00001389239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002056451,0.00003278979,0.0004258959,0.00006129112,0.000007201608,0.00007095507,0.00001013559,0.00002150755,0.9974183,0.00003510137,0.00001152507,0.00169956],"study_design_scores_gemma":[0.00003887306,0.00236075,0.01832744,0.00002276122,0.00003261073,0.000688491,0.00003963541,0.0004970321,0.9772585,0.00003641471,0.0006933729,0.000004109482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962046,0.001549845,0.001471012,0.00004602637,0.00001794188,0.00002599706,0.00005787922,0.0000223348,0.0006044464],"genre_scores_gemma":[0.9974512,0.0009036439,0.001104196,0.0000309476,0.00001086067,0.00002516171,0.00007041248,0.000002936515,0.0004005955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00105619,"threshold_uncertainty_score":0.003533304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03940114782718897,"score_gpt":0.3120619347106823,"score_spread":0.2726607868834933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}