{"id":"W1992259067","doi":"10.1097/aln.0b013e31817f4c5d","title":"Enhancement of Spinal N -Methyl-d-aspartate Receptor Function by Remifentanil Action at δ-Opioid Receptors as a Mechanism for Acute Opioid-induced Hyperalgesia or Tolerance","year":2008,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Remifentanil; NMDA receptor; Hyperalgesia; Opioid; Medicine; Pharmacology; Anesthesia; μ-opioid receptor; Naltrindole; Enkephalin; Opioid receptor; (+)-Naloxone; Receptor; Internal medicine; Nociception","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001945953,0.0003250285,0.00068711,0.000105065,0.0002442985,0.000003808898,0.0001055862,0.0003044617,0.0004737586],"category_scores_gemma":[0.0000719959,0.0002540503,0.0001762852,0.0001649168,0.00006346776,0.00009053461,0.0000259522,0.0001370383,0.0001549614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002436369,"about_ca_system_score_gemma":0.0001447831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001544676,"about_ca_topic_score_gemma":0.00001543632,"domain_scores_codex":[0.9981179,0.0001160798,0.0004904497,0.0005742979,0.0002467257,0.0004545082],"domain_scores_gemma":[0.9989019,0.0000871317,0.0003144209,0.0003437358,0.000187155,0.0001656783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01051026,0.0003992707,0.001526248,0.00007820225,0.0003303788,0.00007618749,0.0002458727,3.040329e-7,0.9766655,0.0004088434,0.00389117,0.005867764],"study_design_scores_gemma":[0.003788776,0.01762361,0.00308151,0.0001045745,0.0003807463,0.0005711548,0.0001134601,0.00003821258,0.9615698,0.0008343246,0.01162292,0.0002708418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968901,0.0001689483,0.0007587399,0.0002809447,0.0006779131,0.001093502,0.00001155777,0.00007351751,0.00004480419],"genre_scores_gemma":[0.9840795,0.0019449,0.005259246,0.0016363,0.0001612825,0.0004616604,0.0002774072,0.000053464,0.006126226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01722434,"threshold_uncertainty_score":0.9999912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03940114782718897,"score_gpt":0.3120619347106823,"score_spread":0.2726607868834933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}