{"id":"W1992273782","doi":"10.1038/nm1125","title":"The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers","year":2004,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":514,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; University of California, San Francisco; National Institutes of Health","keywords":"GTPase; Oncology; Internal medicine; Medicine; Small GTPase; Biology; Cancer research; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001757423,0.00009581172,0.000113463,0.00002583427,0.00008714606,0.00000485009,0.00009661435,0.0001546507,0.000004705907],"category_scores_gemma":[0.0001289341,0.00005772216,0.00002675612,0.00007573105,0.0002193126,0.000001477162,0.00003522543,0.0001177481,1.782222e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001253971,"about_ca_system_score_gemma":0.0000845086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008060416,"about_ca_topic_score_gemma":0.000140766,"domain_scores_codex":[0.9994593,0.00002545725,0.0001365325,0.0001573274,0.0001054231,0.0001159324],"domain_scores_gemma":[0.9995397,0.00001493438,0.00009932789,0.0001850437,0.0001002384,0.0000607149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003025559,0.00001575338,0.0007767928,0.0000672781,0.00005630242,0.00002167982,0.0000875685,0.000114489,0.9507608,0.001382101,0.0001829936,0.04623169],"study_design_scores_gemma":[0.004419214,0.0003526222,0.01310264,0.0006270525,0.00007327592,0.0003424056,0.0001592463,0.00005954811,0.9405342,0.00123118,0.038847,0.0002516129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9660628,0.02942994,0.0008540617,0.002961653,0.0002264339,0.0001861602,0.00001366408,0.000007652408,0.0002576679],"genre_scores_gemma":[0.9984365,0.0005027402,0.0002304443,0.0003392135,0.0003549891,0.0000082632,0.00002921983,0.000008698509,0.00008994596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04598008,"threshold_uncertainty_score":0.2353841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005539968522632137,"score_gpt":0.2463552933565467,"score_spread":0.2408153248339145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}