{"id":"W1992276619","doi":"10.1186/1756-6606-4-20","title":"GPCR oligomers in pharmacology and signaling","year":2011,"lang":"en","type":"review","venue":"Molecular Brain","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Institute of Mental Health; University of Toronto; Centre for Addiction and Mental Health","keywords":"G protein-coupled receptor; Heterotrimeric G protein; Internalization; Receptor; Signal transduction; Function (biology); G protein; Effector; Intracellular; Neuroscience; Computational biology; Cell biology; Biology; Chemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004204763,0.000429839,0.0008247224,0.0001997758,0.00004232582,0.00002520527,0.0002812923,0.0005651301,0.0001447614],"category_scores_gemma":[0.00004715725,0.000414256,0.0002872947,0.0001644667,0.00006765208,0.000002449689,0.0002051127,0.0003003796,0.00001658268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002416702,"about_ca_system_score_gemma":0.0001356146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001438006,"about_ca_topic_score_gemma":0.000005442464,"domain_scores_codex":[0.9980206,0.000333041,0.0004469518,0.0006926653,0.00009164622,0.0004151062],"domain_scores_gemma":[0.9993755,0.00002729123,0.0001755309,0.0002694062,0.00002481492,0.0001274828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001696756,0.00006511434,0.00000392334,0.002676866,0.0003236986,0.0001729163,0.00007311525,0.00000894188,0.388939,0.0004042657,0.0009403033,0.6063749],"study_design_scores_gemma":[0.0003280552,0.0001146742,2.315977e-7,0.0007927102,0.0001610901,0.00006418157,0.00001431596,0.000003527409,0.03681469,0.00009225509,0.9611034,0.0005108144],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002349359,0.9953019,0.001132167,0.00001890942,0.0002431061,0.0004792552,0.00001202261,0.00001237722,0.0004508741],"genre_scores_gemma":[0.0005238854,0.9975344,0.0007153663,0.000443434,0.0001640978,0.0001091476,0.0001706039,0.0001005944,0.000238453],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9601632,"threshold_uncertainty_score":0.9998309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02269878161442701,"score_gpt":0.30789688824977,"score_spread":0.285198106635343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}