{"id":"W1992278190","doi":"10.1002/pd.2502","title":"Second and first trimester estimation of risk for Down syndrome: implementation and performance in the SAFER study","year":2010,"lang":"en","type":"article","venue":"Prenatal Diagnosis","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University; Queen's University; Mount Sinai Hospital; University of Manitoba; The Society of Obstetricians and Gynaecologists of Canada","funders":"Canadian Institutes of Health Research; Fetal Medicine Foundation","keywords":"Medicine; False positive rate; False positive paradox; Nuchal translucency; Obstetrics; Nuchal Translucency Measurement; Pregnancy; Down syndrome; First trimester; Gynecology; Fetus; Statistics; Biology; Genetics; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02960496,0.0004516698,0.0005343864,0.0008997786,0.0001956396,0.001077922,0.0007350799,0.000614546,0.001862037],"category_scores_gemma":[0.03931779,0.0004108566,0.0007077047,0.0004800073,0.0003973754,0.0009363836,0.001482955,0.0006992199,0.0004668389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006527266,"about_ca_system_score_gemma":0.001103311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002118297,"about_ca_topic_score_gemma":0.002231644,"domain_scores_codex":[0.98094,0.01349478,0.0009552753,0.001483578,0.002768417,0.0003579682],"domain_scores_gemma":[0.9581908,0.01867572,0.01163342,0.005036311,0.00416038,0.002303345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006228971,0.0005562683,0.9367182,0.00008751896,0.0001992472,0.00007080867,0.0007359679,0.0006415613,0.0007588678,0.0001665081,0.0003347934,0.05350125],"study_design_scores_gemma":[0.0008114945,0.01200119,0.9727957,0.00006824585,0.0003451327,0.0006382144,0.0003273396,0.008051825,0.002821818,0.0001683765,0.001924627,0.00004599484],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952101,0.0002924817,0.002289602,0.0001554635,0.00001310296,0.0001883469,0.0002786717,0.00004616932,0.001526146],"genre_scores_gemma":[0.9928442,0.0001432537,0.005852598,0.00007077964,0.00002636758,0.0001598024,0.0003588292,0.00001764274,0.0005264781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02960496,"threshold_uncertainty_score":0.1565679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01265423178443451,"score_gpt":0.2897086462157307,"score_spread":0.2770544144312961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}