{"id":"W1992278190","doi":"10.1002/pd.2502","title":"Second and first trimester estimation of risk for Down syndrome: implementation and performance in the SAFER study","year":2010,"lang":"en","type":"article","venue":"Prenatal Diagnosis","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University; Queen's University; Mount Sinai Hospital; University of Manitoba; The Society of Obstetricians and Gynaecologists of Canada","funders":"Canadian Institutes of Health Research; Fetal Medicine Foundation","keywords":"Medicine; False positive rate; False positive paradox; Nuchal translucency; Obstetrics; Nuchal Translucency Measurement; Pregnancy; Down syndrome; First trimester; Gynecology; Fetus; Statistics; Biology; Genetics; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003663805,0.0000912824,0.0001564161,0.00007528108,0.00007404394,0.00002379217,0.00005388095,0.00004415564,0.00004081853],"category_scores_gemma":[0.0003837793,0.00006403116,0.00002151792,0.00008803191,0.00004812991,0.0001588317,0.00004145507,0.0001396531,0.000001033004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006443415,"about_ca_system_score_gemma":0.00001359075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001566973,"about_ca_topic_score_gemma":0.0009288813,"domain_scores_codex":[0.9993674,0.00002607389,0.0002094705,0.0001603084,0.0001208438,0.0001159356],"domain_scores_gemma":[0.9986738,0.001028211,0.00007691306,0.0001497666,0.00002910324,0.00004220763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001064836,0.000201048,0.9523702,0.0001810687,0.00002071654,0.000003999648,0.001963624,0.000007666249,0.000005724914,0.00003155521,0.0001403551,0.04496758],"study_design_scores_gemma":[0.002763311,0.0008697239,0.9927069,0.0000776416,0.0001241251,0.00003977522,0.0005686697,0.001048825,0.001549008,0.00006842982,0.0001116693,0.00007194595],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982549,0.0001348035,0.00005032046,0.0001877924,0.0000544333,0.001101558,0.0001477562,0.00000977723,0.00005868737],"genre_scores_gemma":[0.9985936,0.0001065261,0.0007819422,0.00004529335,0.00001738258,0.0003794221,0.00006294588,0.000007670104,0.000005196628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04489563,"threshold_uncertainty_score":0.2611115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01265423178443451,"score_gpt":0.2897086462157307,"score_spread":0.2770544144312961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}