{"id":"W1992295816","doi":"10.1371/journal.pone.0015845","title":"Tissue-Specific Analysis of Glycogen Synthase Kinase-3α (GSK-3α) in Glucose Metabolism: Effect of Strain Variation","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Internal medicine; Endocrinology; Glycogen synthase; Insulin resistance; Insulin; Skeletal muscle; Carbohydrate metabolism; GSK-3; Biology; Type 2 diabetes; Glycogen; Diabetes mellitus; Metabolism; Kinase; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004782476,0.0007405031,0.0003259619,0.0004361628,0.0002172281,0.0004153348,0.0004546842,0.0003510398,0.00226713],"category_scores_gemma":[0.0002014675,0.000278448,0.0004787826,0.0003789102,0.0006352851,0.0002719922,0.0004055496,0.001173642,0.0005183074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003313194,"about_ca_system_score_gemma":0.0003047443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005797672,"about_ca_topic_score_gemma":0.001416695,"domain_scores_codex":[0.9995533,0.00005836811,0.0000621837,0.0001747948,0.00009500508,0.00005643087],"domain_scores_gemma":[0.9994679,0.00007006481,0.0002150725,0.00009748348,0.00003923531,0.0001103392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002038248,0.00005105534,0.0003094672,0.00003605976,0.000007623357,0.00001797308,0.000008342476,0.00003887991,0.9985671,0.00004031205,0.00001297829,0.0007063771],"study_design_scores_gemma":[0.00002955138,0.0007162861,0.011688,0.00001204083,0.00008034868,0.0002137295,0.00002314373,0.0002662612,0.9857351,0.00004740739,0.001178137,0.000009953139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983274,0.003196296,0.01027268,0.000173949,0.0001104823,0.0001315076,0.001178702,0.0001218899,0.00154041],"genre_scores_gemma":[0.9762613,0.003331167,0.01150013,0.000246638,0.00004443917,0.0003284456,0.002148213,0.0002301477,0.005909544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00226713,"threshold_uncertainty_score":0.007584274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02941483264319163,"score_gpt":0.2300637664545053,"score_spread":0.2006489338113137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}