{"id":"W1992312576","doi":"10.1074/jbc.m110.197657","title":"Inflammatory Cytokines Determine the Susceptibility of Human CD8 T Cells to Fas-mediated Activation-induced Cell Death through Modulation of FasL and c-FLIPS Expression","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Programmed cell death; CD8; T cell; Fas ligand; Cytotoxic T cell; TCIRG1; Cell biology; Apoptosis; Cytokine; Biology; Molecular biology; Chemistry; Immunology; Interleukin 21; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001335505,0.0002809616,0.0001911685,0.000131766,0.0001081967,0.0003014389,0.00007891437,0.0002671923,0.00178929],"category_scores_gemma":[0.000218784,0.00009584233,0.0001604087,0.0001081272,0.0001810642,0.0002160924,0.0001324454,0.0005685981,0.0003507992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001667079,"about_ca_system_score_gemma":0.0001367991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001854095,"about_ca_topic_score_gemma":0.0002424253,"domain_scores_codex":[0.9998146,0.00004095216,0.00002291785,0.0000265114,0.00003851056,0.00005665747],"domain_scores_gemma":[0.9998603,0.00004144299,0.00003697366,0.00001222571,0.0000209145,0.00002819084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003407143,0.00003002406,0.0002723436,0.00003799286,0.000003507282,0.00004836448,0.00003238431,0.00005849814,0.9980485,0.00002928975,0.00001603217,0.001082332],"study_design_scores_gemma":[0.00005389616,0.000832904,0.005841085,0.00001135253,0.00001891688,0.0004204025,0.00005429473,0.0003967387,0.9910687,0.00008441852,0.001211746,0.000005606551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961671,0.002161372,0.0007858021,0.00005903028,0.00001425136,0.00002681047,0.00013716,0.00001402888,0.0006343189],"genre_scores_gemma":[0.9972551,0.0009686142,0.0006649403,0.00004280534,0.00001193937,0.00003453817,0.000192793,0.000003895017,0.0008254067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00178929,"threshold_uncertainty_score":0.005985796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04318952035575763,"score_gpt":0.2478915183436563,"score_spread":0.2047019979878987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}