{"id":"W1992320105","doi":"10.1097/00004714-200104000-00009","title":"Diphenhydramine Alters the Disposition of Venlafaxine Through Inhibition of CYP2D6 Activity in Humans","year":2001,"lang":"en","type":"article","venue":"Journal of Clinical Psychopharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Medical Research Council; Heart and Stroke Foundation of Canada","keywords":"Diphenhydramine; Venlafaxine; Pharmacology; CYP2D6; Antihistamine; Venlafaxine Hydrochloride; Drug interaction; Concomitant; Pharmacokinetics; Oral administration; Diphenhydramine hydrochloride; Medicine; Chemistry; Endocrinology; Internal medicine; Antidepressant; Histamine; Cytochrome P450; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001674198,0.0001487939,0.0002461331,0.0001256058,0.0001211583,0.0001903374,0.00005691046,0.0001679175,0.001145929],"category_scores_gemma":[0.0003622325,0.00009881011,0.0001495732,0.00008105347,0.0001379282,0.0001066138,0.00007489542,0.0002054393,0.000121189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00011737,"about_ca_system_score_gemma":0.00004935501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003441869,"about_ca_topic_score_gemma":0.0004284308,"domain_scores_codex":[0.9998813,0.00004683051,0.000008891341,0.00002786687,0.00002003985,0.00001507083],"domain_scores_gemma":[0.9999141,0.00002366006,0.00002645824,0.0000127903,0.000004671479,0.00001832686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0327156,0.002640958,0.3346522,0.0001931634,0.0004587435,0.002985966,0.000401676,0.0004673363,0.5021408,0.0004336858,0.001077292,0.1218324],"study_design_scores_gemma":[0.0003751687,0.02035234,0.9423691,0.00000990648,0.0001391155,0.004279597,0.00008434557,0.0007606392,0.02773572,0.000140419,0.003741915,0.00001165544],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998702,0.0004731666,0.0002327772,0.00001942838,0.00000613075,0.000009633945,0.00004917792,0.000006293326,0.0005014865],"genre_scores_gemma":[0.9992736,0.0001627859,0.0001395907,0.00003377844,0.000007552193,0.000005063962,0.0000458094,0.000001668685,0.0003301997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001145929,"threshold_uncertainty_score":0.003833532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1900052992042785,"score_gpt":0.5480024974528064,"score_spread":0.3579971982485278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}