{"id":"W1992330420","doi":"10.1021/jo901824h","title":"A Modular Synthesis of Alkynyl-Phosphocholine Headgroups for Labeling Sphingomyelin and Phosphatidylcholine","year":2009,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Sphingomyelin; Phosphocholine; Bioorthogonal chemistry; Chemistry; Sphingomyelin phosphodiesterase; Sphingolipid; Alkyne; Combinatorial chemistry; Phosphatidylcholine; Biochemistry; Phospholipid; Click chemistry; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002598399,0.0008541551,0.0002955494,0.0003462979,0.0002560531,0.0002458591,0.0005021421,0.0005663683,0.001513525],"category_scores_gemma":[0.0001985521,0.0003328425,0.0003452448,0.0002680087,0.0002517994,0.0005730341,0.000452074,0.000735522,0.0008732832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004065766,"about_ca_system_score_gemma":0.0006504401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005062184,"about_ca_topic_score_gemma":0.001041847,"domain_scores_codex":[0.9998698,0.00001114609,0.00001049274,0.00003084673,0.00004396509,0.0000337022],"domain_scores_gemma":[0.9998918,0.00001344337,0.00003354735,0.00001693651,0.00001371899,0.00003061756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004281517,0.00003549526,0.00005601331,0.00008183885,0.000007410772,0.0001542922,0.00002309095,0.0003817117,0.9912443,0.0008270974,0.0001039598,0.007041997],"study_design_scores_gemma":[0.00002954461,0.0003025654,0.0004080115,0.000007030395,0.00001517145,0.0003897154,0.000005819777,0.0006602537,0.990642,0.000188624,0.007336167,0.00001515063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6424142,0.004542851,0.3379548,0.0005840922,0.0003431031,0.001357665,0.00127905,0.001797332,0.009726977],"genre_scores_gemma":[0.7571961,0.004535894,0.2239111,0.0002016295,0.00006887526,0.0006830223,0.001133901,0.0001571759,0.01211228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001513525,"threshold_uncertainty_score":0.005063176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009317989893446987,"score_gpt":0.2417205860312585,"score_spread":0.2324025961378115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}