{"id":"W1992336689","doi":"10.1128/aac.03999-14","title":"Inhibition of Endoplasmic Reticulum-Resident Glucosidases Impairs Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63 Spike Protein-Mediated Entry by Altering the Glycan Processing of Angiotensin I-Converting Enzyme 2","year":2014,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health","keywords":"Endoplasmic reticulum; Glycoprotein; Biology; Glucosidases; Glycan; Viral envelope; Viral entry; Coronavirus; Cell biology; Biochemistry; Virology; Enzyme; Virus; Viral replication; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001437634,0.0003993014,0.0003081697,0.0001019096,0.0001096581,0.0002738989,0.0001940713,0.0002683843,0.0004469989],"category_scores_gemma":[0.0001134501,0.0001361109,0.000279626,0.000106436,0.0002328619,0.0001623123,0.0001313038,0.0004637274,0.0001499596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002294212,"about_ca_system_score_gemma":0.0001959772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006666489,"about_ca_topic_score_gemma":0.0007918457,"domain_scores_codex":[0.9998181,0.00003789572,0.00003299415,0.00002790708,0.00004084239,0.0000421938],"domain_scores_gemma":[0.9999292,0.00001235458,0.00002139029,0.000009658606,0.000006272472,0.00002113992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001391204,0.00006358029,0.00006638515,0.00001461972,0.000004671846,0.00002776344,0.000009730606,0.00004012962,0.9992261,0.00003877637,0.00001293324,0.0003561644],"study_design_scores_gemma":[0.00003386772,0.0007882671,0.002685619,0.000002855147,0.00001508088,0.0001145159,0.00001749263,0.0009212082,0.9944658,0.00002443433,0.0009265558,0.000004417375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983151,0.0004401081,0.0005250377,0.00003660615,0.00002407077,0.00002002864,0.0001138938,0.00002719057,0.0004980921],"genre_scores_gemma":[0.9974436,0.0003504101,0.0009107885,0.0000347259,0.000008658812,0.00002673545,0.0002645646,0.000009662349,0.0009509152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006666489,"threshold_uncertainty_score":0.001664579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02160110587201716,"score_gpt":0.297594774048685,"score_spread":0.2759936681766679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}