{"id":"W1992351445","doi":"10.1007/s00395-014-0411-3","title":"The adapter protein c-Cbl-associated protein (CAP) protects from acute CVB3-mediated myocarditis through stabilization of type I interferon production and reduced cytotoxicity","year":2014,"lang":"en","type":"article","venue":"Basic Research in Cardiology","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Ottawa; Heart and Stroke Foundation; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis Foundation","keywords":"Viral Myocarditis; Interferon; Myocarditis; IRF3; Interferon regulatory factors; Biology; Cytotoxic T cell; Signal transducing adaptor protein; Cytotoxicity; Inflammation; Immunology; Cancer research; Cell biology; Signal transduction; Innate immune system; In vitro; Medicine; Immune system; Virus; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002263858,0.0004477945,0.0004232171,0.0003337471,0.0003554293,0.000503665,0.0004488781,0.0004025447,0.001472849],"category_scores_gemma":[0.0002639999,0.0001714018,0.0002933502,0.0001983322,0.0003144667,0.0002578242,0.0003215542,0.001251843,0.0004590809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004014873,"about_ca_system_score_gemma":0.0004549207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009015808,"about_ca_topic_score_gemma":0.001015288,"domain_scores_codex":[0.99981,0.00002459077,0.00001282635,0.00002509018,0.00003802211,0.0000893682],"domain_scores_gemma":[0.9998198,0.00001266544,0.00004905042,0.00002849187,0.00002377449,0.00006627844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00244186,0.0002447197,0.0004079693,0.00007862561,0.00002544962,0.00007916621,0.00001061293,0.0001076709,0.9917991,0.00009168906,0.0002871993,0.004426051],"study_design_scores_gemma":[0.0006226043,0.002244424,0.01418492,0.0000217293,0.00009241099,0.0004241794,0.00003852436,0.001594639,0.9775173,0.0001217986,0.003119898,0.00001754304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937789,0.002710046,0.001530023,0.0002376184,0.0001320597,0.00004020053,0.0003373488,0.0001657258,0.001068025],"genre_scores_gemma":[0.9971106,0.0004563317,0.0008173564,0.00008606588,0.0000454748,0.00003458808,0.0004833301,0.00001997338,0.0009461904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001472849,"threshold_uncertainty_score":0.004927218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07050229968968517,"score_gpt":0.356217308029364,"score_spread":0.2857150083396788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}