{"id":"W1992362863","doi":"10.1038/nprot.2012.066","title":"Convergent synthesis of aminomethylene peptidomimetics","year":2012,"lang":"en","type":"article","venue":"Nature Protocols","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Peptidomimetic; Aziridine; Peptide; Peptide bond; Combinatorial chemistry; Amide; Conjugate; Chemistry; Peptide synthesis; Convergent synthesis; Cysteine; Solid-phase synthesis; Stereochemistry; Amino acid; Biochemistry; Organic chemistry; Ring (chemistry); Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004025161,0.0003912877,0.0003899758,0.0002674846,0.0002574435,0.0003858063,0.0005739929,0.0003946585,0.003087704],"category_scores_gemma":[0.0005071024,0.0002294962,0.0002371301,0.0002672488,0.0002175594,0.0005013238,0.0005080538,0.001122832,0.001293462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005504663,"about_ca_system_score_gemma":0.0005431791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002780599,"about_ca_topic_score_gemma":0.0008774244,"domain_scores_codex":[0.9996865,0.00003796451,0.00002602307,0.0000511509,0.0001303564,0.00006803175],"domain_scores_gemma":[0.9998418,0.00003379075,0.00003192725,0.00001791284,0.00003199659,0.00004254258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000226332,0.00005792532,0.00008668289,0.0002632003,0.00002139628,0.0003431549,0.0000991225,0.001479754,0.9639359,0.01061029,0.0007189465,0.02215718],"study_design_scores_gemma":[0.00006070358,0.0003609061,0.0002614263,0.00002179611,0.00001800334,0.0002319017,0.00001840012,0.002243572,0.9765995,0.001392168,0.01877103,0.00002066523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.8004827,0.005597155,0.1377685,0.0008259884,0.0007850059,0.0005933446,0.002129254,0.001045094,0.05077294],"genre_scores_gemma":[0.8942655,0.004018145,0.08166347,0.0002648448,0.00007940588,0.0003542522,0.0009947545,0.0001449607,0.01821469],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.003087704,"threshold_uncertainty_score":0.01032937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01044393429140861,"score_gpt":0.2984638020349405,"score_spread":0.2880198677435319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}