{"id":"W1992370033","doi":"10.1002/ijc.25401","title":"Metastasis‐focused cell‐based SELEX generates aptamers inhibiting cell migration and invasion","year":2010,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; Agence Nationale de la Recherche","keywords":"Aptamer; Systematic evolution of ligands by exponential enrichment; Biology; Cell; Intracellular; Cell culture; Metastasis; Cancer cell; Cancer research; Tyrosine kinase; SELEX Aptamer Technique; Cell biology; Cell migration; Cancer; Molecular biology; RNA; Biochemistry; Signal transduction; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004038587,0.0006338354,0.0004834535,0.0001824395,0.0001364038,0.0004303004,0.0003127512,0.0003993206,0.001011174],"category_scores_gemma":[0.000339471,0.0002006595,0.0002619994,0.0001652488,0.0003212491,0.0002321012,0.0003656796,0.0005478266,0.0004334087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002442922,"about_ca_system_score_gemma":0.0001727593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002073895,"about_ca_topic_score_gemma":0.0004397295,"domain_scores_codex":[0.9997796,0.00004818139,0.00002087374,0.00004113666,0.00007516664,0.00003504887],"domain_scores_gemma":[0.9998497,0.00006493808,0.00002577254,0.00002234876,0.0000183541,0.00001889875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004274736,0.00002872587,0.0001126319,0.00002635662,0.000007855672,0.00006086297,0.00002013833,0.0008848574,0.9965496,0.0001509624,0.00003524757,0.00208007],"study_design_scores_gemma":[0.000007689983,0.00009706917,0.0001336403,0.000001721269,0.000007950252,0.00008921264,0.000008874647,0.001504023,0.9973513,0.0000379128,0.0007567405,0.000003741842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9556493,0.0004402761,0.04089271,0.0001202966,0.00002641659,0.0001620337,0.0002869342,0.0001909854,0.002231129],"genre_scores_gemma":[0.9703039,0.0007248264,0.02277775,0.0001155287,0.000006806075,0.0001381907,0.0006155254,0.00006939714,0.005247979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001011174,"threshold_uncertainty_score":0.003382683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009023986809376196,"score_gpt":0.2851033726168912,"score_spread":0.276079385807515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}