{"id":"W1992373328","doi":"10.1189/jlb.0610357","title":"TLR engagement prior to virus infection influences MHC-I antigen presentation in an epitope-dependent manner as a result of nitric oxide release","year":2010,"lang":"en","type":"article","venue":"Journal of Leukocyte Biology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation; University of Ottawa; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; TLR3; Epitope; TLR2; Innate immune system; Antigen presentation; Antigen; Immunology; TLR4; Acquired immune system; Cross-presentation; Toll-like receptor; Immune system; Major histocompatibility complex; MHC class I; T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001456124,0.0001507468,0.0003605075,0.0007569393,0.00009533598,0.00001455421,0.0002406305,0.0003249066,0.0001869743],"category_scores_gemma":[0.0007978744,0.0001221862,0.00009599212,0.0002412934,0.0001034384,0.0004108682,0.00006859309,0.0006284298,0.000112018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007263124,"about_ca_system_score_gemma":0.0002065416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001148612,"about_ca_topic_score_gemma":0.0003479607,"domain_scores_codex":[0.997627,0.0009056963,0.0009606399,0.0001863188,0.00006592141,0.000254384],"domain_scores_gemma":[0.9985022,0.0002017333,0.0007297334,0.0002197813,0.000304531,0.00004202393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002453727,0.0001717581,0.03043146,0.00001088646,0.00007818298,0.00001593207,0.0005613557,0.0001764229,0.9538783,0.0001411969,0.0001842004,0.01189659],"study_design_scores_gemma":[0.001414481,0.00091659,0.3178618,0.00002927721,0.00002631183,0.0001288982,0.0001419145,0.000005128309,0.6623755,0.0001186173,0.01687242,0.0001090632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976545,0.0008619753,0.0001009066,0.0002396013,0.0007576327,0.000284493,0.000003816923,0.00001199116,0.0000851068],"genre_scores_gemma":[0.9983067,0.001061594,0.0001667167,0.0001691384,0.00009104668,0.00001080177,0.00002040203,0.00001021049,0.0001634216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2915028,"threshold_uncertainty_score":0.4982608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01852108292255315,"score_gpt":0.3180856087295821,"score_spread":0.299564525807029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}