{"id":"W1992398204","doi":"10.1038/mt.2008.98","title":"Central Delivery of Dicer-substrate siRNA: A Direct Application for Pain Research","year":2008,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Dicer; Substrate (aquarium); Small interfering RNA; Cell biology; Chemistry; Neuroscience; Biology; RNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004434093,0.0007160423,0.0005923299,0.0004089627,0.0002426526,0.000433157,0.0003518271,0.0007978248,0.00187557],"category_scores_gemma":[0.0002235653,0.0002000781,0.0004128515,0.0001795759,0.0004149112,0.0003242522,0.0003376979,0.0007657004,0.00065928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003761074,"about_ca_system_score_gemma":0.0002845038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003490984,"about_ca_topic_score_gemma":0.0004936408,"domain_scores_codex":[0.9996792,0.00004742816,0.00002670277,0.0001066062,0.0001004492,0.00003957815],"domain_scores_gemma":[0.9998593,0.00002388657,0.00003257809,0.00002058028,0.00003913164,0.00002451153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003017154,0.00001124912,0.00001524086,0.00009100657,0.000003281742,0.00002654374,0.000007662985,0.00001817623,0.9976491,0.0001004638,0.00006451837,0.001982467],"study_design_scores_gemma":[0.00001155752,0.0003272532,0.0002871026,0.000006109226,0.00001491297,0.000229303,0.00000584639,0.0003359138,0.9956392,0.00003413314,0.003103261,0.000005448287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7019234,0.02663711,0.248434,0.001368049,0.0007263298,0.001244162,0.001372812,0.001793196,0.01650096],"genre_scores_gemma":[0.870841,0.01033833,0.104362,0.000478356,0.0001530069,0.0006615004,0.0008975597,0.0001238418,0.01214435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00187557,"threshold_uncertainty_score":0.006274462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04500031268235093,"score_gpt":0.3099383786243258,"score_spread":0.2649380659419748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}