{"id":"W1992462013","doi":"10.1039/c4md00197d","title":"Prekinamycin and an isosteric-isoelectronic analogue exhibit comparable cytotoxicity towards K562 human leukemia cells","year":2014,"lang":"en","type":"article","venue":"MedChemComm","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; American Chemical Society Petroleum Research Fund","keywords":"K562 cells; Cytotoxicity; Leukemia; Chemistry; Cancer research; Stereochemistry; Computational biology; Combinatorial chemistry; Biology; Biochemistry; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003203583,0.0002415152,0.0002667152,0.00004235097,0.0001722901,0.00005870278,0.0002738773,0.0001782315,0.00004813832],"category_scores_gemma":[0.000006770196,0.0002391737,0.00007313066,0.00007636098,0.00008341816,0.000007523333,0.0001505552,0.0001631313,0.000007603832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006974128,"about_ca_system_score_gemma":0.00008358597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002115569,"about_ca_topic_score_gemma":0.000477133,"domain_scores_codex":[0.9986404,0.00009809709,0.0002154407,0.0004809824,0.0001399686,0.000425108],"domain_scores_gemma":[0.9991177,0.000007253372,0.00009009248,0.0005590629,0.00005080893,0.0001751381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004436839,0.00005832807,0.0001740574,0.00002312294,0.00003432472,8.783915e-7,0.0000784026,0.00002660145,0.9945911,0.0006531104,0.0004492374,0.003866456],"study_design_scores_gemma":[0.0007813632,0.001002377,0.0007868304,0.00001127423,0.00002973295,0.00001002499,0.00003533695,0.0007394936,0.9580316,0.0007942219,0.03747025,0.00030752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918599,0.0004514114,0.004785891,0.00007811357,0.0001000079,0.0002019848,0.0000160303,0.00003052042,0.002476193],"genre_scores_gemma":[0.9973015,0.0001328414,0.0005204228,0.0008048958,0.0002873374,0.00003110569,0.0001495545,0.00003875583,0.0007335733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03702101,"threshold_uncertainty_score":0.9753219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412376737643227,"score_gpt":0.2730744756405786,"score_spread":0.2589507082641463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}