{"id":"W1992493472","doi":"10.1053/j.gastro.2013.08.008","title":"Bile Acids Increase Levels of MicroRNAs 221 and 222, Leading to Degradation of CDX2 During Esophageal Carcinogenesis","year":2013,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"United European Gastroenterology; Japan Society for the Promotion of Science; Smoking Research Foundation; Fonds Wetenschappelijk Onderzoek; National Research Foundation of Korea; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Mitsukoshi Health and Welfare Foundation; École Polytechnique Fédérale de Lausanne; National Science Foundation; Keio University; Canadian Institute for Theoretical Astrophysics","keywords":"Bile acid; CDX2; Gene knockdown; microRNA; Barrett's esophagus; Carcinogenesis; Cancer research; Receptor; Chemistry; Biology; Transcription factor; Molecular biology; Internal medicine; Adenocarcinoma; Endocrinology; Medicine; Biochemistry; Cancer; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001219285,0.0001160082,0.0002347531,0.00009914697,0.00003689924,0.000004251493,0.00009468076,0.0001165082,0.00001974865],"category_scores_gemma":[0.00003278322,0.0001062241,0.00004858532,0.00005195488,0.00008186672,0.00000531856,0.000103028,0.00004865456,0.000006698619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001162724,"about_ca_system_score_gemma":0.00002510568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002065276,"about_ca_topic_score_gemma":0.00004766052,"domain_scores_codex":[0.9990371,0.0001081967,0.000298821,0.0002411826,0.00006119834,0.0002534477],"domain_scores_gemma":[0.9994616,0.000008150756,0.000132989,0.0001760163,0.0001052695,0.0001159644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008394715,0.00002424998,0.3548822,0.00006447743,0.00003377257,0.000001258617,0.00004010562,0.0000150923,0.6445283,0.000007457558,0.00004711874,0.0002719486],"study_design_scores_gemma":[0.0006163015,0.0005972169,0.6609731,0.00002758819,0.00001708962,0.000055272,0.00005792657,0.00000496201,0.3375572,0.00000514734,0.00004048635,0.00004773297],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987041,0.0002090412,0.0005139509,0.0001204898,0.00007526183,0.0002402575,0.00003981871,0.000004669753,0.00009244137],"genre_scores_gemma":[0.998975,0.0000388853,0.0005823543,0.0001028725,0.00004363213,0.00001838966,0.00002249296,0.00001336246,0.0002030424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3069712,"threshold_uncertainty_score":0.4331695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008689573000693345,"score_gpt":0.2351084286914007,"score_spread":0.2264188556907073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}