{"id":"W1992493472","doi":"10.1053/j.gastro.2013.08.008","title":"Bile Acids Increase Levels of MicroRNAs 221 and 222, Leading to Degradation of CDX2 During Esophageal Carcinogenesis","year":2013,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"United European Gastroenterology; Japan Society for the Promotion of Science; Smoking Research Foundation; Fonds Wetenschappelijk Onderzoek; National Research Foundation of Korea; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Mitsukoshi Health and Welfare Foundation; École Polytechnique Fédérale de Lausanne; National Science Foundation; Keio University; Canadian Institute for Theoretical Astrophysics","keywords":"Bile acid; CDX2; Gene knockdown; microRNA; Barrett's esophagus; Carcinogenesis; Cancer research; Receptor; Chemistry; Biology; Transcription factor; Molecular biology; Internal medicine; Adenocarcinoma; Endocrinology; Medicine; Biochemistry; Cancer; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002243858,0.0002781049,0.0004547407,0.000350998,0.0003228078,0.0006513529,0.0001088639,0.0004080772,0.002288133],"category_scores_gemma":[0.0003642518,0.0004207667,0.0004239931,0.0001737645,0.0003387977,0.0003868151,0.0003287554,0.0006542781,0.0005520175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000385057,"about_ca_system_score_gemma":0.0003048553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000574736,"about_ca_topic_score_gemma":0.0009780527,"domain_scores_codex":[0.9997335,0.00004765457,0.00002666137,0.00006280142,0.00005531418,0.00007399936],"domain_scores_gemma":[0.999798,0.00003049781,0.00005301679,0.00002260943,0.00003528239,0.00006057404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002555309,0.00004369454,0.00201709,0.00005438522,0.00002810063,0.0001376535,0.00003701789,0.00004783043,0.9931182,0.0001603143,0.000149529,0.001650902],"study_design_scores_gemma":[0.00006325656,0.00040102,0.04727858,0.000009366639,0.00005039888,0.0005079911,0.0001625577,0.0006601054,0.9487339,0.0001579222,0.001961821,0.00001308993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942464,0.002691749,0.001270998,0.000187696,0.00008983533,0.00001358548,0.0002868919,0.00006563323,0.001147163],"genre_scores_gemma":[0.9931676,0.0007262548,0.0009176423,0.0001250358,0.00002160984,0.00003136366,0.0004068904,0.00002369624,0.004580043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002288133,"threshold_uncertainty_score":0.007654548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008689573000693345,"score_gpt":0.2351084286914007,"score_spread":0.2264188556907073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}