{"id":"W1992493959","doi":"10.1021/ac0620056","title":"Signal Response of Coexisting Protein Conformers in Electrospray Mass Spectrometry","year":2007,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Mass Spectrometry Techniques and Applications","field":"Chemistry","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Electrospray ionization; Conformational isomerism; Myoglobin; Mass spectrometry; Ion; Electrospray; Analytical Chemistry (journal); Ionization; Protein folding; Folding (DSP implementation); Chromatography; Crystallography; Molecule; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009120443,0.0002209235,0.0003542172,0.0001143071,0.00004718748,0.00002056642,0.0003410511,0.0002578351,0.007134137],"category_scores_gemma":[0.0003479719,0.0002327715,0.0001460559,0.0008462738,0.0001764274,0.00004979655,0.00005196452,0.0005708652,0.000008908671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002825946,"about_ca_system_score_gemma":0.000106098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002952584,"about_ca_topic_score_gemma":0.000002266243,"domain_scores_codex":[0.997963,0.00001060732,0.0006739838,0.0003832523,0.0003700945,0.0005990874],"domain_scores_gemma":[0.9987993,0.0003161282,0.0001993307,0.0004241175,0.00007957801,0.0001815345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003692152,0.0001294508,0.004308294,0.0001547149,0.00002548002,0.00003122473,0.00001061902,0.000001530047,0.9913564,0.003384628,0.00006307585,0.000165314],"study_design_scores_gemma":[0.0003649058,0.00003436698,0.0006736535,0.00006957433,0.00001883787,0.00001433538,0.0001329761,0.0005350529,0.9952264,0.001734167,0.0009513413,0.0002443284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7952854,0.00003861707,0.003797773,0.0001420865,0.000002458226,0.00008649317,0.00001641773,0.00009949626,0.2005313],"genre_scores_gemma":[0.9908895,0.000004147708,0.005400361,0.00002324182,0.00007378258,0.00002033674,0.00002330687,0.00002577002,0.003539508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1969918,"threshold_uncertainty_score":0.9937735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227566665377408,"score_gpt":0.2827765113122069,"score_spread":0.2705008446584328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}