{"id":"W1992493959","doi":"10.1021/ac0620056","title":"Signal Response of Coexisting Protein Conformers in Electrospray Mass Spectrometry","year":2007,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Mass Spectrometry Techniques and Applications","field":"Chemistry","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Electrospray ionization; Conformational isomerism; Myoglobin; Mass spectrometry; Ion; Electrospray; Analytical Chemistry (journal); Ionization; Protein folding; Folding (DSP implementation); Chromatography; Crystallography; Molecule; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001290001,0.0006964188,0.0004942187,0.0005660135,0.0002676997,0.0007207621,0.0006894742,0.001004981,0.0008687099],"category_scores_gemma":[0.001842674,0.0003545085,0.0002729357,0.0006151089,0.0007580749,0.0008453486,0.0008752201,0.0007836131,0.0003845552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003508775,"about_ca_system_score_gemma":0.0001862613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001941259,"about_ca_topic_score_gemma":0.0001779573,"domain_scores_codex":[0.9989346,0.0002222216,0.00005119712,0.0002744012,0.0004411487,0.00007641403],"domain_scores_gemma":[0.9989761,0.0005349652,0.0001616331,0.00005039846,0.0001848708,0.00009213429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009431275,0.00001540508,0.0003233027,0.00004296625,0.000008789828,0.0000505906,0.00003953773,0.0001194163,0.9971793,0.00006065225,0.00002188073,0.002043969],"study_design_scores_gemma":[0.00001796063,0.0002319608,0.002778525,0.00001038592,0.00001678917,0.0003309036,0.00005784377,0.003819468,0.9919001,0.0002392501,0.0005830337,0.00001381428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9412417,0.00219611,0.05408574,0.0001768747,0.00005163198,0.00009200149,0.0001277436,0.000388386,0.0016398],"genre_scores_gemma":[0.9497784,0.001787438,0.04565858,0.0003178585,0.00004479405,0.0001590673,0.0002793052,0.00009762374,0.001876972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001290001,"threshold_uncertainty_score":0.006822228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227566665377408,"score_gpt":0.2827765113122069,"score_spread":0.2705008446584328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}