{"id":"W1992499963","doi":"10.1038/sj.jea.7500370","title":"Concentration-dependent TCDD elimination kinetics in humans: toxicokinetic modeling for moderately to highly exposed adults from Seveso, Italy, and Vienna, Austria, and impact on dose estimates for the NIOSH cohort","year":2004,"lang":"en","type":"article","venue":"Journal of Exposure Science & Environmental Epidemiology","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":144,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Institute of Environmental Health Sciences; Regione Lombardia; National Institutes of Health; U.S. Environmental Protection Agency","keywords":"Toxicokinetics; Tetrachlorodibenzo-p-dioxin; Chemistry; Cohort; Toxicology; Toxicity; Internal medicine; Medicine; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001787346,0.0002339966,0.0004285022,0.00006799799,0.0002345489,0.00004652208,0.0003202286,0.00008587453,0.00001682299],"category_scores_gemma":[0.001220983,0.0001493016,0.00009000344,0.00009328514,0.0005043068,0.0003081395,0.0001167356,0.000183971,0.000002031444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004048201,"about_ca_system_score_gemma":0.00002062893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001494313,"about_ca_topic_score_gemma":0.00003031011,"domain_scores_codex":[0.9979432,0.0000711558,0.0007551797,0.0004811072,0.0002884323,0.0004609725],"domain_scores_gemma":[0.997818,0.001402571,0.0003541761,0.0001851961,0.00001580461,0.0002242543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.0006650664,0.000224329,0.07859188,0.000007597987,0.00002190531,0.000004804077,0.000647591,0.6279874,0.2869168,0.00008009151,0.00002630954,0.004826189],"study_design_scores_gemma":[0.003810759,0.004086552,0.8624627,0.0001437636,0.0000930792,0.00004885762,0.0005144255,0.09744518,0.02582445,0.005195301,0.00002071774,0.0003541878],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908474,0.0005780839,0.006318154,0.001207081,0.0001296408,0.0008637175,0.00004219563,0.000005031749,0.00000870409],"genre_scores_gemma":[0.9915581,0.000271143,0.007660651,0.000369957,0.00007444165,0.00003654986,0.00001085718,0.00001427703,0.000004055775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7838708,"threshold_uncertainty_score":0.6088341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02360400618503118,"score_gpt":0.3473376300685732,"score_spread":0.323733623883542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}