{"id":"W1992517046","doi":"10.1089/hum.2007.179","title":"Overcoming the Innate Immune Response to Small Interfering RNA","year":2008,"lang":"en","type":"review","venue":"Human Gene Therapy","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":281,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovative Targeting Solutions (Canada)","funders":"","keywords":"Innate immune system; Small interfering RNA; Immune system; Biology; Immunology; RNA; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002792016,0.0006347631,0.0008853438,0.0007292337,0.0001611183,0.0004428141,0.0005492881,0.0006814,0.001345694],"category_scores_gemma":[0.0002087021,0.0001533542,0.000236161,0.0005582596,0.0002995087,0.0004970453,0.0002892601,0.0007662044,0.001954576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004000665,"about_ca_system_score_gemma":0.000368249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004873163,"about_ca_topic_score_gemma":0.0007041939,"domain_scores_codex":[0.9998858,0.00001916054,0.00001100889,0.00001646195,0.00005486304,0.0000127618],"domain_scores_gemma":[0.999923,0.00003213709,0.00001285516,0.000003276073,0.00002165677,0.000006983679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000657604,0.00007270466,0.000205109,0.009723292,0.0000567615,0.000551855,0.00009394318,0.0005498702,0.08344406,0.005474552,0.01064457,0.8891175],"study_design_scores_gemma":[0.00001999743,0.0002131402,0.00120589,0.0008259522,0.00006017403,0.00273571,0.00006073373,0.0002868813,0.03156983,0.002070626,0.9609312,0.00001980226],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001517894,0.991901,0.001697065,0.0002350115,0.0002174347,0.00001324244,0.00001405645,0.00004037071,0.0043639],"genre_scores_gemma":[0.005553015,0.9887291,0.001492579,0.0002856949,0.0001230325,0.00002629528,0.00004108528,0.000004629006,0.003744607],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001345694,"threshold_uncertainty_score":0.00450182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07675055468076773,"score_gpt":0.3271711521197014,"score_spread":0.2504205974389337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}