{"id":"W1992519413","doi":"10.1038/cddis.2011.88","title":"Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm","year":2011,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Aortic aneurysm repair treatments","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; St. Paul's Hospital; University of British Columbia","funders":"Michael Smith Health Research BC; Canadian Institutes of Health Research; Heart and Stroke Foundation of British Columbia and Yukon; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Decorin; Granzyme B; Extracellular matrix; Chemistry; Granzyme; Serine protease; Perforin; Cell biology; Cytotoxic T cell; Proteoglycan; Molecular biology; In vitro; Biochemistry; Protease; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003441499,0.0006776162,0.0006359872,0.0005043239,0.0002007998,0.0003487806,0.0003076002,0.0005790032,0.0009708493],"category_scores_gemma":[0.0002488434,0.0002788324,0.000418986,0.0001781053,0.0004465335,0.0003062702,0.0001771702,0.001302724,0.0002866753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001958537,"about_ca_system_score_gemma":0.0002976884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000399831,"about_ca_topic_score_gemma":0.000777212,"domain_scores_codex":[0.9998277,0.00004108594,0.00002033638,0.00001909138,0.00003596809,0.00005569019],"domain_scores_gemma":[0.9996502,0.00004034782,0.0001308142,0.00003067706,0.00002326803,0.0001245996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003853962,0.001041736,0.0003205965,0.0001060403,0.00003107205,0.0001323818,0.00004552527,0.0002580648,0.9902677,0.00009401765,0.0001050783,0.003743803],"study_design_scores_gemma":[0.0005275628,0.01388018,0.006412004,0.00003077855,0.00008421924,0.000406319,0.00007849183,0.002229105,0.9748217,0.0001287354,0.001383274,0.00001751475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971319,0.0008571472,0.001041034,0.000110755,0.00005612104,0.00003642376,0.0001737472,0.00009001885,0.0005027516],"genre_scores_gemma":[0.9940918,0.001431329,0.001619408,0.00009749608,0.00003743605,0.0001049578,0.0003533913,0.00002552595,0.002238699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009708493,"threshold_uncertainty_score":0.003247797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02343879864993047,"score_gpt":0.237460238246137,"score_spread":0.2140214395962065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}