{"id":"W1992542859","doi":"10.1038/nrmicro2745","title":"Modulating immunity as a therapy for bacterial infections","year":2012,"lang":"en","type":"review","venue":"Nature Reviews Microbiology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":538,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; McGill University; University of British Columbia","funders":"Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Innate immune system; Antimicrobial; Biology; Immunity; Antibiotic resistance; Antibiotics; Immune system; Immunology; Antimicrobial peptides; Pattern recognition receptor; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007965447,0.001682927,0.00196301,0.001743975,0.0002687323,0.001052088,0.0009790988,0.001753545,0.002839105],"category_scores_gemma":[0.0009278622,0.0003615177,0.0004404759,0.001334513,0.0007419844,0.001441921,0.0008129958,0.00366639,0.0021948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004863564,"about_ca_system_score_gemma":0.0007818103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005907622,"about_ca_topic_score_gemma":0.001676954,"domain_scores_codex":[0.9997817,0.0000369903,0.00002921633,0.00003330904,0.00009351251,0.00002530395],"domain_scores_gemma":[0.9996479,0.0001641176,0.00004311264,0.0000116769,0.00008561071,0.00004765776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001539494,0.0001194904,0.00007890149,0.007221158,0.00006607906,0.0001716987,0.00002740235,0.0003541071,0.002824543,0.002714617,0.05574473,0.9305234],"study_design_scores_gemma":[0.00009059459,0.0001521801,0.0004194902,0.002091764,0.0001486322,0.0009696592,0.00003546406,0.0001773893,0.0006837434,0.002191807,0.9930183,0.00002096364],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008557186,0.9975746,0.0002750231,0.0003660743,0.0008611295,0.000007841001,0.00001464481,0.00001244585,0.0008026062],"genre_scores_gemma":[0.00077365,0.9964611,0.0003707294,0.0005277265,0.0008023062,0.000014835,0.00002859797,0.000003297288,0.00101782],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002839105,"threshold_uncertainty_score":0.009497821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04464169390145939,"score_gpt":0.3521310262793412,"score_spread":0.3074893323778818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}