{"id":"W1992554281","doi":"10.1074/jbc.m110.214056","title":"A Central Interdomain Protein Joint in Elongation Factor G Regulates Antibiotic Sensitivity, GTP Hydrolysis, and Ribosome Translocation","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"GTP'; GTPase; Ribosome; Elongation factor; Fusidic acid; EF-Tu; Translation (biology); Guanosine triphosphate; Biochemistry; Protein biosynthesis; Phenylalanine; Chemistry; Cell biology; Biology; Amino acid; Messenger RNA; RNA; Enzyme; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001511513,0.0003981776,0.000232945,0.0001628548,0.0002818507,0.0003233369,0.0002013541,0.0003253217,0.0005871704],"category_scores_gemma":[0.0002215629,0.0001706974,0.0001400044,0.0001301146,0.0005008209,0.0002236858,0.0002722478,0.0003269674,0.0002396058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004360267,"about_ca_system_score_gemma":0.0001708606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002862784,"about_ca_topic_score_gemma":0.0004622423,"domain_scores_codex":[0.9998597,0.00002461912,0.000008422083,0.00004309645,0.00003709694,0.00002701165],"domain_scores_gemma":[0.9998671,0.00002882683,0.000037366,0.00001438943,0.000008438899,0.00004396044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001086907,0.0000103023,0.0002163551,0.000006415484,0.000002405192,0.00006609095,0.000004269219,0.0001222894,0.9988245,0.0001254364,0.00000714541,0.0005060061],"study_design_scores_gemma":[0.00002421598,0.0001682152,0.005475018,0.000002116248,0.00001791053,0.0004371714,0.00001767462,0.002446573,0.9905922,0.0001399727,0.0006732204,0.000005614912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997007,0.0005609383,0.001886933,0.00002610004,0.000005989718,0.000004309561,0.0000164461,0.00003043054,0.0004618143],"genre_scores_gemma":[0.9989318,0.00008520661,0.0006540232,0.000006021198,0.000002506717,0.000002034905,0.00002222539,0.000005540538,0.0002905614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005871704,"threshold_uncertainty_score":0.003163576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02401601342392079,"score_gpt":0.2201056962748618,"score_spread":0.196089682850941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}