{"id":"W1992566894","doi":"10.1139/v09-181","title":"Intramolecular hydroamination of unactivated alkenes with secondary alkylamines catalyzed by iridium phosphino–phenolate complexes","year":2010,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Dalhousie University","keywords":"Hydroamination; Chemistry; Intramolecular force; Piperidine; Cyclooctadiene; Enantiopure drug; Pyrrolidine; Medicinal chemistry; Catalysis; Iridium; Aryl; Amination; Crystal structure; Stereochemistry; Organic chemistry; Enantioselective synthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001611644,0.0002213935,0.0003691785,0.0001412711,0.00009404719,0.00004699884,0.0004225249,0.0002043428,0.002325074],"category_scores_gemma":[0.0001698914,0.0002048451,0.0001307674,0.0004161951,0.0002394649,0.0001774909,0.0000133717,0.0005326214,0.000002628665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001084195,"about_ca_system_score_gemma":0.000998082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00127813,"about_ca_topic_score_gemma":0.0008079855,"domain_scores_codex":[0.9986646,0.00000872795,0.0005297677,0.0001935302,0.0003219505,0.0002814474],"domain_scores_gemma":[0.997962,0.0000519322,0.0006464109,0.0003071912,0.0004876555,0.0005448064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002636222,0.00003726456,0.001023434,0.0001199908,0.0002111279,0.00007003544,0.0001632945,0.00001992342,0.9944654,0.000007022262,0.001093086,0.002763075],"study_design_scores_gemma":[0.0008275483,0.00001288824,0.0001585048,0.00004609038,0.00008565989,0.0002633087,0.000306732,0.00008126853,0.9897772,0.00003947514,0.008176948,0.0002243871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890797,0.000565181,0.0001060575,0.0002330561,0.00006059076,0.00002801543,0.0001458231,0.0000119459,0.009769642],"genre_scores_gemma":[0.9987466,0.00001224129,0.0001366564,0.00003646804,0.00009974386,0.000002064442,0.0002687176,0.00003341658,0.0006640956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009666908,"threshold_uncertainty_score":0.998587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002626626680563573,"score_gpt":0.1756378136636608,"score_spread":0.1730111869830972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}