{"id":"W1992566894","doi":"10.1139/v09-181","title":"Intramolecular hydroamination of unactivated alkenes with secondary alkylamines catalyzed by iridium phosphino–phenolate complexes","year":2010,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Dalhousie University","keywords":"Hydroamination; Chemistry; Intramolecular force; Piperidine; Cyclooctadiene; Enantiopure drug; Pyrrolidine; Medicinal chemistry; Catalysis; Iridium; Aryl; Amination; Crystal structure; Stereochemistry; Organic chemistry; Enantioselective synthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000166898,0.0004172979,0.0002269607,0.0001365893,0.00009101279,0.0002409425,0.0004104409,0.0001927372,0.0007185931],"category_scores_gemma":[0.0001919028,0.0001779537,0.0001806861,0.000117463,0.0002115071,0.0002038918,0.0002891303,0.0005223209,0.0002932257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003066927,"about_ca_system_score_gemma":0.0002052345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000473311,"about_ca_topic_score_gemma":0.001153152,"domain_scores_codex":[0.9998296,0.00001836818,0.00001534423,0.00003451781,0.00004701841,0.00005513721],"domain_scores_gemma":[0.9999028,0.00001489855,0.00003214465,0.00001720435,0.00001555155,0.0000174112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006465669,0.00001695342,0.00005761511,0.00006178122,0.000007278381,0.00008392771,0.00002920039,0.0001105433,0.9977773,0.0001916122,0.00004538212,0.001553735],"study_design_scores_gemma":[0.000008270122,0.00007427071,0.0002104964,0.000001751639,0.000005413457,0.00005261341,0.000004804187,0.0002204896,0.9987673,0.00000927533,0.000643341,0.00000215615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902974,0.0007884213,0.004260405,0.00005082759,0.00002512513,0.00003921738,0.0001226224,0.0001312634,0.004284704],"genre_scores_gemma":[0.9956816,0.0004676906,0.001970377,0.00001335538,0.00000654018,0.00001606276,0.0001174653,0.0000217211,0.001705176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007185931,"threshold_uncertainty_score":0.002403915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002626626680563573,"score_gpt":0.1756378136636608,"score_spread":0.1730111869830972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}