{"id":"W1992571724","doi":"10.1089/nat.2011.0315","title":"Branched, Tripartite-Interfering RNAs Silence Multiple Target Genes with Long Guide Strands","year":2012,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"RNA interference; Trans-acting siRNA; Gene silencing; Small interfering RNA; Dicer; RNA silencing; RNA-induced silencing complex; Argonaute; Cell biology; RNA; Biology; RNA-induced transcriptional silencing; Gene; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000141094,0.0003290306,0.0001820193,0.0001767138,0.0001118432,0.00027148,0.0003455628,0.0003386062,0.0008082873],"category_scores_gemma":[0.0002089877,0.0001596994,0.0002651168,0.0001352275,0.0001913207,0.0002590525,0.0002298976,0.0003903405,0.0004645092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003093775,"about_ca_system_score_gemma":0.0002247444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001507021,"about_ca_topic_score_gemma":0.0003634771,"domain_scores_codex":[0.9998676,0.0000247258,0.00001257333,0.00003619467,0.00004146341,0.00001747756],"domain_scores_gemma":[0.9998183,0.00003270244,0.0000695864,0.00001906478,0.00003067069,0.00002974313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002747591,0.00001070697,0.00005701731,0.00003727537,0.000008481416,0.00003537528,0.000006640635,0.0001652375,0.9970207,0.0003264325,0.00002114995,0.002283475],"study_design_scores_gemma":[0.00001601005,0.0005271395,0.0007640534,0.000006359059,0.00002804333,0.0003421036,0.00001163566,0.001728838,0.9917387,0.0002162598,0.00461143,0.000009512608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.926388,0.002711033,0.06559649,0.0001179058,0.00008529695,0.0001447359,0.0003223143,0.0003236827,0.004310586],"genre_scores_gemma":[0.9499682,0.001010698,0.04393668,0.0001608545,0.00001809484,0.0001147515,0.0005561571,0.00004557223,0.00418894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008082873,"threshold_uncertainty_score":0.002704024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01855921964285014,"score_gpt":0.257787656382952,"score_spread":0.2392284367401019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}