{"id":"W1992572718","doi":"10.1016/j.bbaexp.2006.05.001","title":"The role of Sp1 and Sp3 in the constitutive DPYD gene expression","year":2006,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"DPYD; Dihydropyrimidine dehydrogenase; Chromatin immunoprecipitation; Sp1 transcription factor; Activator (genetics); Promoter; Molecular biology; Transcription (linguistics); Biology; Gene; Chemistry; Gene expression; Genetics; Fluorouracil; Pharmacogenetics; Thymidylate synthase; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003017354,0.0002773796,0.0002851154,0.0002711518,0.0003679542,0.0005554048,0.0004062957,0.0003814391,0.001188251],"category_scores_gemma":[0.0003215527,0.0002910874,0.0002650397,0.0001928807,0.0004929267,0.0005562956,0.0004375752,0.0009767457,0.0004669322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005338038,"about_ca_system_score_gemma":0.000316164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008449833,"about_ca_topic_score_gemma":0.0008792765,"domain_scores_codex":[0.9998436,0.00002516238,0.00001747838,0.00004650165,0.00003229857,0.00003492062],"domain_scores_gemma":[0.9996657,0.0000989291,0.00004150085,0.00006713101,0.000052275,0.00007438107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000131099,0.0000098684,0.0005788297,0.00002675481,0.000003352237,0.00006207742,0.00002106436,0.00003054056,0.9961213,0.0007657692,0.00002627704,0.002223098],"study_design_scores_gemma":[0.00001790003,0.00008134411,0.01142063,0.000005631504,0.00001001753,0.000441785,0.00004869343,0.0007530068,0.9850895,0.0007207106,0.001404615,0.00000615655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745875,0.005159064,0.01626416,0.0003186577,0.00005737532,0.00002954755,0.0005106375,0.0001376109,0.002935506],"genre_scores_gemma":[0.9925272,0.000607862,0.003903929,0.00004740099,0.00001887289,0.00002286797,0.0003505742,0.00003883713,0.002482334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001188251,"threshold_uncertainty_score":0.003975093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00346415336911605,"score_gpt":0.2179590055230829,"score_spread":0.2144948521539669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}